PPAP2C Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

PPAP2C: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. Belongs to the PA-phosphatase related phosphoesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.4; Phosphatase, lipid; Motility/polarity/chemotaxis; Lipid Metabolism - sphingolipid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerolipid; Membrane protein, multi-pass; Membrane protein, integral; Lipid Metabolism - glycerophospholipid

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: lipid phosphatase activity; phosphatidate phosphatase activity; phosphoprotein phosphatase activity; protein binding

Biological Process: phospholipid dephosphorylation; phospholipid metabolic process; protein amino acid dephosphorylation; signal transduction; sphingolipid biosynthetic process; sphingolipid metabolic process