IRS1 Antibody – Rabbit Polyclonal

IRS1: an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2q36

Cellular Component: caveola; cytoplasm; cytosol; intracellular membrane-bound organelle; nucleus; plasma membrane

Molecular Function: insulin receptor binding; insulin-like growth factor receptor binding; phosphoinositide 3-kinase binding; protein binding; protein kinase C binding; SH2 domain binding; signal transducer activity; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: activation of MAPKK activity; axon guidance; cellular response to insulin stimulus; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; glucose homeostasis; innate immune response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; lipid catabolic process; mammary gland development; MAPKKK cascade; negative regulation of insulin receptor signaling pathway; negative regulation of insulin secretion; nerve growth factor receptor signaling pathway; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of phosphoinositide 3-kinase activity; protein kinase B signaling cascade; Ras protein signal transduction; regulation of gene expression; response to insulin stimulus; response to peptide hormone stimulus; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway

Disease: Diabetes Mellitus, Noninsulin-dependent