IRF8 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

IRF8: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family.

Protein type: DNA-binding; Transcription factor

Cellular Component: nucleoplasm; nucleus

Molecular Function: DNA binding; protein binding; transcription factor activity

Biological Process: defense response to bacterium; defense response to protozoan; immune response; myeloid cell differentiation; phagocytosis; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to bacterium; transcription, DNA-dependent