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RBM35B (ESRP2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150050

RBM35B Antibody: RBM35A, also known as ESRP2, is a mRNA splicing factor that with its related protein RBM35A (ESRP1) are coordinators of an epithelial cell-type-specific splicing program. Both RBM35B and RBM35A are involved in posttranscriptional regulation… More details

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Product Overview

Online Datasheet in PDF
Product Name
RBM35B (ESRP2), Polyclonal Antibody
Full Product Name
RBM35B Antibody
Product Gene Name
anti-ESRP2 antibody
Product Synonym Names
RBM35B; RBM35B; RBM35B; PP7059; Epithelial splicing regulatory protein 2; RNA-binding motif protein 35B; epithelial splicing regulatory protein 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
RBM35B Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
RBM35B antibody is predicted to not cross-react with other RBM35/ESRP family members. At least three isoforms of RBM35B are known to exist; this antibody will detect all three.
Preparation and Storage
RBM35B antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
RBM35B peptide (MBS152526) is used for blocking the activity of RBM35B antibody (MBS150050)
Molecular Weight
77,364 Da
OMIM
612960
3D Structure
ModBase 3D Structure for Q9H6T0
Conjugate
Unconjugated
Immunogen
RBM35B antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human RBM35B.
Buffer
RBM35B Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-ESRP2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ESRP2 antibody
RBM35B antibody can be used for detection of RBM35B by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-ESRP2 antibody

Western blot analysis of RBM35B in human lung tissue lysate with RBM35B antibody at 1 μg/mL.
Rabbit Anti-ESRP2 Polyclonal Antibody – Cat# MBS150050

Immunohistochemistry (IHC) of anti-ESRP2 antibody

Immunohistochemistry of RBM35B in human lung tissue with RBM35B antibody at 5 μg/mL.
Rabbit Anti-ESRP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150050

Immunofluorescence (IF) of anti-ESRP2 antibody

Immunofluorescence of RBM35B in human lung tissue cells with RBM35B antibody at 20 μg/mL.
Rabbit Anti-ESRP2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150050

Other Notes

Small volumes of anti-ESRP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ESRP2 purchase

MBS150050 is an antibody targeting ESRP2. Also known as RBM35B Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ESRP2. It may not necessarily be applicable to this product.

NCBI GI #
45935393
NCBI GeneID
80004
NCBI Accession #
NP_079215
UniProt Primary Accession #
Q9H6T0
UniProt Secondary Accession #
Q8N6H8; Q8WZ15; Q9H6I4
UniProt Related Accession #
Q9H6T0
GenBank Nucleotide #
NM_024939.2
NCBI Official Full Name
epithelial splicing regulatory protein 2
NCBI Official Synonym Full Names
epithelial splicing regulatory protein 2
NCBI Official Symbol
ESRP2
NCBI Official Synonym Symbols
RBM35B
UniProt Protein Name
Epithelial splicing regulatory protein 2
UniProt Synonym Protein Names
RNA-binding motif protein 35B; RNA-binding protein 35B
Protein Family
Epithelial splicing regulatory protein
UniProt Gene Name
ESRP2
UniProt Synonym Gene Names
RBM35B
UniProt Entry Name
ESRP2_HUMAN
NCBI Protein Information
epithelial splicing regulatory protein 2; RNA-binding protein 35B; RNA binding motif protein 35A; RNA binding motif protein 35B; RNA-binding motif protein 35B

NCBI Summary for ESRP2

ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

UniProt Comments for ESRP2

RBM35B: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Belongs to the ESRP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: mRNA binding; nucleotide binding

Biological Process: regulation of RNA splicing; RNA splicing; mRNA processing
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Research Articles on ESRP2

1. ESRP1 and ESRP2 suppress cancer cell motility via different mechanisms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ESRP2 antibody

 Reference Product  PubMed Publications
 FGFR2 antibody  >6 publications with ESRP2 and FGFR2
 CD44 antibody  >4 publications with ESRP2 and CD44
 CTNND1 antibody  >2 publications with ESRP2 and CTNND1
 ENAH antibody  >2 publications with ESRP2 and ENAH
 ST14 antibody  >1 publications with ESRP2 and ST14

Diseases associated with anti-ESRP2 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with ESRP2 and Breast Neoplasms
 Skin Diseases Antibodies  >2 publications with ESRP2 and Skin Diseases
 Lung Diseases Antibodies  >1 publications with ESRP2 and Lung Diseases

Organs/Tissues associated with anti-ESRP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lymph Antibodies  >2 publications with ESRP2 and Lymph
 Lymph Node Antibodies  >2 publications with ESRP2 and Lymph Node
 Nerve Antibodies  >1 publications with ESRP2 and Nerve
 Connective Tissue Antibodies  >1 publications with ESRP2 and Connective Tissue
 Prostate Antibodies  >1 publications with ESRP2 and Prostate
 Placenta Antibodies  >1 publications with ESRP2 and Placenta
 Skin Antibodies  >1 publications with ESRP2 and Skin
 Brain Antibodies  >1 publications with ESRP2 and Brain
 Lung Antibodies  >1 publications with ESRP2 and Lung
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