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PARL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150055

PARL Antibody: PARL is a mitochondrial integral membrane protein and a member of the highly conserved rhomboid superfamily of membrane proteins. PARL is required for the control of apoptosis during postnatal growth and is required for the processing of OPA1,… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PARL, Polyclonal Antibody
Full Product Name
PARL Antibody
Product Gene Name
anti-PARL antibody
Product Synonym Names
PARL; PSARL; PSARL1; RHBDS1; PRO2207; PSENIP2; PSARL; Presenilins-associated rhomboid-like protein; mitochondrial; Mitochondrial intramembrane cleaving protease PARL; Pbeta; presenilin associated, rhomboid-like
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
PARL Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
Antibody can be stored at 4 degree C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
PARL peptide (MBS152958) is used for blocking the activity of PARL antibody (MBS150055)
Molecular Weight
36,589 Da
OMIM
607858
3D Structure
ModBase 3D Structure for Q9H300
Conjugate
Unconjugated
Immunogen
PARL antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human PARL.
Buffer
PARL Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-PARL antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-PARL antibody
PARL antibody can be used for detection of PARL by Western blot at 1 - 2 mug/mL. Despite its predicted molecular weight of ~42kDa, PARL is observed at a higher molecular weight in SDS-PAGE. Antibody can also be used for immunocytochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-PARL antibody

Western blot analysis of PARL in 3T3 cell lysate with PARL antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-PARL Polyclonal Antibody – Cat# MBS150055

Immunocytochemistry (IHC) of anti-PARL antibody

Immunocytochemistry of PARL in 3T3 cells with PARL antibody at 2.5 μg/mL.
Rabbit Anti-PARL Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS150055

Immunofluorescence (IF) of anti-PARL antibody

Immunofluorescence of PARL in 3T3 cells with PARL antibody at 2.50 μg/mL.
Rabbit Anti-PARL Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150055

Other Notes

Small volumes of anti-PARL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PARL purchase

MBS150055 is an antibody targeting PARL. Also known as PARL Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PARL. It may not necessarily be applicable to this product.

NCBI GI #
143811433
NCBI GeneID
55486
NCBI Accession #
Q9H300.2
UniProt Primary Accession #
Q9H300
UniProt Secondary Accession #
Q96CQ4; Q9BTJ6; Q9P1E3
UniProt Related Accession #
Q9H300
NCBI Official Full Name
Presenilins-associated rhomboid-like protein, mitochondrial
NCBI Official Synonym Full Names
presenilin associated, rhomboid-like
NCBI Official Symbol
PARL
NCBI Official Synonym Symbols
PSARL; PSARL1; RHBDS1; PRO2207; PSENIP2
UniProt Protein Name
Presenilins-associated rhomboid-like protein, mitochondrial
UniProt Synonym Protein Names
Mitochondrial intramembrane cleaving protease PARLP-beta; Pbeta
Protein Family
Presenilins-associated rhomboid-like protein
UniProt Gene Name
PARL
UniProt Synonym Gene Names
PSARL; Pbeta
UniProt Entry Name
PARL_HUMAN
NCBI Protein Information
presenilins-associated rhomboid-like protein, mitochondrial; rhomboid 7 homolog 1; mitochondrial intramembrane cleaving protease PARL; mitochondrial intramembrane-cleaving protease PARL

NCBI Summary for PARL

This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for PARL

PSARL: a mitochondrial intramembrane protease that is associated with insulin resistance and type 2 diabetes. Induced in humans by caloric restriction. Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain. Induced in humans by caloric restriction. Interacts with PSEN1 and PSEN2. Binds OPA1. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral; Protease; EC 3.4.21.105; Membrane protein, multi-pass; Mitochondrial

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane; nucleus

Molecular Function: protein binding; serine-type endopeptidase activity; endopeptidase activity

Biological Process: membrane protein proteolysis; proteolysis
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Research Articles on PARL

1. the frequency of the haplotype AAC, and AAT were significantly higher in the unaffected cases and the frequencies of haplotype GGT were significantly higher in LHON cases

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PARL antibody

 Reference Product  PubMed Publications
 HAX1 antibody  >2 publications with PARL and HAX1

Diseases associated with anti-PARL antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >17 publications with PARL and Nervous System Diseases
 Disease Models, Animal Antibodies  >7 publications with PARL and Disease Models, Animal
 Heart Diseases Antibodies  >4 publications with PARL and Heart Diseases
 Necrosis Antibodies  >4 publications with PARL and Necrosis
 Kidney Diseases Antibodies  >3 publications with PARL and Kidney Diseases
 Precancerous Conditions Antibodies  >2 publications with PARL and Precancerous Conditions
 Cardiomegaly Antibodies  >1 publications with PARL and Cardiomegaly
 Anemia, Hemolytic Antibodies  >1 publications with PARL and Anemia, Hemolytic
 Hypertrophy Antibodies  >1 publications with PARL and Hypertrophy
 Anemia Antibodies  >1 publications with PARL and Anemia

Organs/Tissues associated with anti-PARL antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >26 publications with PARL and Brain
 Blood Antibodies  >24 publications with PARL and Blood
 Muscle Antibodies  >11 publications with PARL and Muscle
 Vascular Antibodies  >7 publications with PARL and Vascular
 Liver Antibodies  >5 publications with PARL and Liver
 Heart Antibodies  >5 publications with PARL and Heart
 Eye Antibodies  >5 publications with PARL and Eye
 Uterus Antibodies  >4 publications with PARL and Uterus
 Nerve Antibodies  >3 publications with PARL and Nerve
 Prostate Antibodies  >2 publications with PARL and Prostate
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