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SKA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150123

SKA2 Antibody: Upon entry into mitosis, the cell's microtubule (MT) network forms the mitotic spindle, allowing the segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SKA2, Polyclonal Antibody
Full Product Name
SKA2 Antibody
Product Gene Name
anti-SKA2 antibody
Product Synonym Names
SKA2; FAM33A; FAM33A; Spindle and kinetochore-associated protein 2; Protein FAM33A; spindle and kinetochore associated complex subunit 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
SKA2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
SKA2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
SKA2 peptide (MBS152129) is used for blocking the activity of SKA2 antibody (MBS150123)
Molecular Weight
8,282 Da
3D Structure
ModBase 3D Structure for Q8WVK7
Conjugate
Unconjugated
Immunogen
SKA2 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human SKA2.
Buffer
SKA2 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-SKA2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-SKA2 antibody
SKA2 antibody can be used for detection of SKA2 by Western blot at 0.5 - 1 mug/mL.

Western Blot (WB) of anti-SKA2 antibody

Western blot analysis of SKA2 in 3T3 cell lysate with SKA2 antibody at (A) 0.5 and (B) 1 μg/mL.
Rabbit Anti-SKA2 Polyclonal Antibody – Cat# MBS150123

Other Notes

Small volumes of anti-SKA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SKA2 purchase

MBS150123 is an antibody targeting SKA2. Also known as SKA2 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SKA2. It may not necessarily be applicable to this product.

NCBI GI #
32699054
NCBI GeneID
348235
NCBI Accession #
NP_872426
UniProt Primary Accession #
Q8WVK7
UniProt Secondary Accession #
A6NIL3; B3KPL3; E9PCB8
UniProt Related Accession #
Q8WVK7
GenBank Nucleotide #
NM_182620.3
NCBI Official Full Name
spindle and kinetochore-associated protein 2 isoform 1
NCBI Official Synonym Full Names
spindle and kinetochore associated complex subunit 2
NCBI Official Symbol
SKA2
NCBI Official Synonym Symbols
FAM33A
UniProt Protein Name
Spindle and kinetochore-associated protein 2
UniProt Synonym Protein Names
Protein FAM33A
Protein Family
Spindle and kinetochore-associated protein
UniProt Gene Name
SKA2
UniProt Synonym Gene Names
FAM33A
UniProt Entry Name
SKA2_HUMAN
NCBI Protein Information
spindle and kinetochore-associated protein 2; spindle and KT (kinetochore) associated 2; family with sequence similarity 33, member A

UniProt Comments for SKA2

SKA2: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Belongs to the SKA2 family.

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: spindle microtubule; outer kinetochore of condensed chromosome; cytosol

Molecular Function: protein binding; microtubule binding

Biological Process: mitosis; cell division; mitotic cell cycle; regulation of microtubule polymerization or depolymerization; chromosome segregation
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Research Articles on SKA2

1. The structure of the Ska core complex is a W-shaped dimer of coiled coils, formed by intertwined interactions between Ska1, Ska2, and Ska3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SKA2 antibody

 Reference Product  PubMed Publications
 SKA1 antibody  >12 publications with SKA2 and SKA1
 SKA3 antibody  >9 publications with SKA2 and SKA3
 BUB1B antibody  >1 publications with SKA2 and BUB1B

Pathways associated with anti-SKA2 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Resolution Of Sister Chromatid Cohesion Pathway antibodies  Resolution Of Sister Chromatid Cohesion Pathway Diagram
 Separation Of Sister Chromatids Pathway antibodies  Separation Of Sister Chromatids Pathway Diagram

Diseases associated with anti-SKA2 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with SKA2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with SKA2 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with SKA2 and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with SKA2 and Kidney Diseases

Organs/Tissues associated with anti-SKA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with SKA2 and Blood
 Lung Antibodies  >2 publications with SKA2 and Lung
 Liver Antibodies  >2 publications with SKA2 and Liver
 Bone Antibodies  >1 publications with SKA2 and Bone
 Brain Antibodies  >1 publications with SKA2 and Brain
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