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BNIP3L Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150132

Bnip3L Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik,… More details

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Product Overview

Online Datasheet in PDF
Product Name
Bnip3L, Polyclonal Antibody
Full Product Name
Bnip3L Antibody
Product Gene Name
anti-BNIP3L antibody
Product Synonym Names
Bnip3L; NIX; BNIP3a; BNIP3A; BNIP3H; NIX; Adenovirus E1B19K-binding protein B5; NIP3L; BCL2/adenovirus E1B 19kDa interacting protein 3-like
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Bnip3L Antibody is affinity chromatography purified via peptide column.
Preparation and Storage
Bnip3L antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
Bnip3L peptide (MBS151894) is used for blocking the activity of Bnip3L antibody (MBS150132)
Molecular Weight
40 kDa
OMIM
605368
3D Structure
ModBase 3D Structure for O60238
Conjugate
Unconjugated
Immunogen
Bnip3L antibody was raised against a 16 amino acid peptide near the center of human Bnip3L.
Buffer
Bnip3L Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-BNIP3L antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-BNIP3L antibody
Bnip3L antibody can be used for detection of Bnip3L by Western blot at 1 mug/mL. The approximate 40 kDa top band represents monomer of Bnip3L (4). Antibody can also be used for immunohistochemistry starting at 2 mug/mL. For immunofluorescence start at 10 mug/mL.

Western Blot (WB) of anti-BNIP3L antibody

Western blot analysis of Bnip3L in K562 whole cell lysate in (A) the absence, or (B) presence of immunogenic peptide with Bnip3L antibody at 1 μg/mL.
Rabbit Anti-BNIP3L Polyclonal Antibody – Cat# MBS150132

Immunohistochemistry (IHC) of anti-BNIP3L antibody

Immunohistochemical staining of human kidney tissue using Bnip3L antibody at 2 μg/mL.
Rabbit Anti-BNIP3L Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150132

Immunofluorescence (IF) of anti-BNIP3L antibody

Immunofluorescence of Bnip3L in Human Kidney tissue with Bnip3L antibody at 10 μg/mL.
Rabbit Anti-BNIP3L Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150132

Other Notes

Small volumes of anti-BNIP3L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BNIP3L purchase

MBS150132 is an antibody targeting BNIP3L. Also known as Bnip3L Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BNIP3L. It may not necessarily be applicable to this product.

NCBI GI #
4138825
NCBI GeneID
665
NCBI Accession #
AF067396
UniProt Primary Accession #
O60238
UniProt Secondary Accession #
Q5JW63; Q8NF87; B0AZS9
UniProt Related Accession #
O60238
NCBI Official Full Name
Homo sapiens NIX (NIX) mRNA, nuclear gene encoding mitochondrial protein, complete cds
NCBI Official Synonym Full Names
BCL2/adenovirus E1B 19kDa interacting protein 3-like
NCBI Official Symbol
BNIP3L
NCBI Official Synonym Symbols
NIX; BNIP3a
UniProt Protein Name
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
UniProt Synonym Protein Names
Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; NIP3-like protein X; NIP3L
Protein Family
BCL2/adenovirus E1B 19 kDa protein-interacting protein
UniProt Gene Name
BNIP3L
UniProt Synonym Gene Names
BNIP3A; BNIP3H; NIX; NIP3L
UniProt Entry Name
BNI3L_HUMAN
NCBI Protein Information
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3L; NIP3-like protein X; adenovirus E1B19k-binding protein B5; BCL2/adenovirus E1B 19-kd protein-interacting protein 3a; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A

NCBI Summary for BNIP3L

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein counteracts the apoptotic inducer BNIP3 and may play a role in tumor suppression. [provided by RefSeq, Mar 2011]
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UniProt Comments for BNIP3L

BNIP3L: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. May function as a tumor suppressor. Self-associates. Interacts with BNIP3 and STEAP3. Interacts with SPATA18/MIEAP. Interacts with human adenovirus-2 E1B 19 kDa protein. Belongs to the NIP3 family.

Protein type: Apoptosis; Membrane protein, integral; Mitochondrial; Endoplasmic reticulum; Nuclear envelope

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: mitochondrial outer membrane; mitochondrion; endoplasmic reticulum; integral to membrane; nuclear envelope; intrinsic to membrane

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity; lamin binding

Biological Process: viral reproduction; positive regulation of apoptosis; defense response to virus; negative regulation of apoptosis
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Research Articles on BNIP3L

1. Nix protein positively regulates NF-kappaB activation in gliomas

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BNIP3L antibody

 Reference Product  PubMed Publications
 BNIP3 antibody  >95 publications with BNIP3L and BNIP3
 BCL2 antibody  >22 publications with BNIP3L and BCL2
 HIF1A antibody  >20 publications with BNIP3L and HIF1A
 BCL2L1 antibody  >14 publications with BNIP3L and BCL2L1
 TP53 antibody  >4 publications with BNIP3L and TP53
 ERBB2 antibody  >2 publications with BNIP3L and ERBB2
 CREBBP antibody  >1 publications with BNIP3L and CREBBP

Pathways associated with anti-BNIP3L antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram

Diseases associated with anti-BNIP3L antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >15 publications with BNIP3L and Cardiovascular Diseases
 Heart Diseases Antibodies  >14 publications with BNIP3L and Heart Diseases
 Necrosis Antibodies  >14 publications with BNIP3L and Necrosis
 Breast Neoplasms Antibodies  >13 publications with BNIP3L and Breast Neoplasms
 Nervous System Diseases Antibodies  >8 publications with BNIP3L and Nervous System Diseases
 Brain Diseases Antibodies  >7 publications with BNIP3L and Brain Diseases
 Cardiomyopathies Antibodies  >6 publications with BNIP3L and Cardiomyopathies
 Liver Neoplasms Antibodies  >5 publications with BNIP3L and Liver Neoplasms
 Lung Diseases Antibodies  >5 publications with BNIP3L and Lung Diseases
 Neoplasm Metastasis Antibodies  >5 publications with BNIP3L and Neoplasm Metastasis

Organs/Tissues associated with anti-BNIP3L antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >21 publications with BNIP3L and Heart
 Blood Antibodies  >18 publications with BNIP3L and Blood
 Muscle Antibodies  >16 publications with BNIP3L and Muscle
 Liver Antibodies  >10 publications with BNIP3L and Liver
 Vascular Antibodies  >10 publications with BNIP3L and Vascular
 Brain Antibodies  >10 publications with BNIP3L and Brain
 Lung Antibodies  >8 publications with BNIP3L and Lung
 Kidney Antibodies  >5 publications with BNIP3L and Kidney
 Prostate Antibodies  >5 publications with BNIP3L and Prostate
 Embryonic Tissue Antibodies  >4 publications with BNIP3L and Embryonic Tissue
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