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ZGPAT Antibody – Chicken Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150133

ZGPAT Antibody: The Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT), is a transcriptional repressor that regulates several cellular pathways including EGFR pathways that are involved in cell proliferation, migration and survival. ZGPAT… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ZGPAT, Polyclonal Antibody
Full Product Name
ZGPAT Antibody
Product Gene Name
anti-ZGPAT antibody
Product Synonym Names
ZGPAT; ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847; ZIP; Zinc finger CCCH-type with G patch domain-containing protein; G patch domain-containing protein 6; zinc finger, CCCH-type with G patch domain
Clonality
Polyclonal
Isotype
IgY
Host
Chicken
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
ZGPAT Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
Multiple isoforms of ZGPAT are known to exist.
Preparation and Storage
ZGPAT antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
ZGPAT peptide (MBS153119) is used for blocking the activity of ZGPAT antibody (MBS150133)
Molecular Weight
20,697 Da
3D Structure
ModBase 3D Structure for Q8N5A5
Conjugate
Unconjugated
Immunogen
ZGPAT antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ZGPAT.
Buffer
ZGPAT Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-ZGPAT antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-ZGPAT antibody
ZGPAT antibody can be used for detection of ZGPAT by Western blot at 1 mug/mL. Antibody can also be used for immunofluorescence starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-ZGPAT antibody

Western blot analysis of ZGPAT in SK-N-SH cell lysate with ZGPAT antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Chicken Anti-ZGPAT Polyclonal Antibody – Cat# MBS150133

Immunofluorescence (IF) of anti-ZGPAT antibody

Immunofluorescence of ZGPAT in human brain cells with ZGPAT antibody at 20 μg/mL.
Chicken Anti-ZGPAT Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150133

Other Notes

Small volumes of anti-ZGPAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZGPAT purchase

MBS150133 is an antibody targeting ZGPAT. Also known as ZGPAT Antibody. Reactive in Human. Host: Chicken.

Additional Details

NCBI/Uniprot data below describe general gene information for ZGPAT. It may not necessarily be applicable to this product.

NCBI GI #
133925793
NCBI GeneID
84619
NCBI Accession #
NP_115916
UniProt Primary Accession #
Q8N5A5
UniProt Secondary Accession #
Q4VXN9; Q5JWI9; Q5JWJ0; Q8NC55; Q8WUV4; Q96JI0; Q96JU4; Q9H401; E1P5K1
UniProt Related Accession #
Q8N5A5
GenBank Nucleotide #
NM_032527.4
NCBI Official Full Name
zinc finger CCCH-type with G patch domain-containing protein isoform a
NCBI Official Synonym Full Names
zinc finger, CCCH-type with G patch domain
NCBI Official Symbol
ZGPAT
NCBI Official Synonym Symbols
ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847
UniProt Protein Name
Zinc finger CCCH-type with G patch domain-containing protein
UniProt Synonym Protein Names
G patch domain-containing protein 6; Zinc finger CCCH domain-containing protein 9; Zinc finger and G patch domain-containing protein
UniProt Gene Name
ZGPAT
UniProt Synonym Gene Names
GPATC6; GPATCH6; KIAA1847; ZC3H9; ZC3HDC9; ZIP
UniProt Entry Name
ZGPAT_HUMAN
NCBI Protein Information
zinc finger CCCH-type with G patch domain-containing protein; g patch domain-containing protein 6; zinc finger CCCH domain-containing protein 9; zinc finger and G patch domain-containing protein

UniProt Comments for ZGPAT

ZGPAT: Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding; metal ion binding; transcription factor activity

Biological Process: negative regulation of epidermal growth factor receptor activity; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
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Research Articles on ZGPAT

1. sZIP, an alternative splice variant of ZIP, antagonizes transcription repression and growth inhibition by ZIP in liver neoplasms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-ZGPAT antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with ZGPAT and Inflammation

Organs/Tissues associated with anti-ZGPAT antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >3 publications with ZGPAT and Skin
 Brain Antibodies  >2 publications with ZGPAT and Brain
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