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GRIK4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150165

Grik4 Antibody: Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Grik4, Polyclonal Antibody
Full Product Name
Grik4 Antibody
Product Gene Name
anti-GRIK4 antibody
Product Synonym Names
Grik4; KA1; EAA1; GRIK; GluK4; Glutamate receptor ionotropic; kainate 4; Excitatory amino acid receptor 1; glutamate receptor, ionotropic, kainate 4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Grik4 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
Grik4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
Grik4 peptide (MBS151925) is used for blocking the activity of Grik4 antibody (MBS150165)
Molecular Weight
107,246 Da
OMIM
600282
3D Structure
ModBase 3D Structure for Q16099
Conjugate
Unconjugated
Immunogen
Grik4 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of the human Grik4.
Buffer
Grik4 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-GRIK4 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-GRIK4 antibody
Grik4 antibody can be used for detection of Grik4 by Western blot at 0.5 - 2 mug/mL. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-GRIK4 antibody

Western blot analysis of Grik4 in rat brain lysate with Grik4 antibody at (A) 0.5 (B) 1 and (C) 2 μg/mL.
Rabbit Anti-GRIK4 Polyclonal Antibody – Cat# MBS150165

Immunohistochemistry (IHC) of anti-GRIK4 antibody

Immunohistochemical staining of human brain tissue using Grik4 antibody at 2.5 μg/mL.
Rabbit Anti-GRIK4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150165

Immunofluorescence (IF) of anti-GRIK4 antibody

Immunofluorescence of Grik4 in Human Brain cells with Grik4 antibody at 20 μg/mL.
Rabbit Anti-GRIK4 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150165

Other Notes

Small volumes of anti-GRIK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRIK4 purchase

MBS150165 is an antibody targeting GRIK4. Also known as Grik4 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GRIK4. It may not necessarily be applicable to this product.

NCBI GI #
209572625
NCBI GeneID
2900
NCBI Accession #
Q16099.2
UniProt Primary Accession #
Q16099
UniProt Secondary Accession #
A8K9L1
UniProt Related Accession #
Q16099
NCBI Official Full Name
Glutamate receptor ionotropic, kainate 4
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, kainate 4
NCBI Official Symbol
GRIK4
NCBI Official Synonym Symbols
KA1; EAA1; GRIK; GluK4
UniProt Protein Name
Glutamate receptor ionotropic, kainate 4
UniProt Synonym Protein Names
Excitatory amino acid receptor 1; EAA1; Glutamate receptor KA-1; KA1
Protein Family
Glutamate receptor ionotropic
UniProt Gene Name
GRIK4
UniProt Synonym Gene Names
GRIK; GluK4; EAA1; KA1
UniProt Entry Name
GRIK4_HUMAN
NCBI Protein Information
glutamate receptor ionotropic, kainate 4; glutamate receptor KA1; glutamate receptor KA-1; excitatory amino acid receptor 1

NCBI Summary for GRIK4

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
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UniProt Comments for GRIK4

GluR KA1: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK4 subfamily.

Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; dendrite; plasma membrane; terminal button; perikaryon; cell junction; nucleus

Molecular Function: extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; glutamate signaling pathway; transport; ionotropic glutamate receptor signaling pathway; response to corticosteroid stimulus
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Research Articles on GRIK4

1. The deletion allele affords protection against bipolar disorder through increased KA1 protein abundance in neuronal cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRIK4 antibody

 Reference Product  PubMed Publications
 GRIK2 antibody  >5 publications with GRIK4 and GRIK2
 KCNJ5 antibody  >2 publications with GRIK4 and KCNJ5
 GRIN2B antibody  >1 publications with GRIK4 and GRIN2B
 GRIN2D antibody  >1 publications with GRIK4 and GRIN2D
 KCNJ1 antibody  >1 publications with GRIK4 and KCNJ1

Pathways associated with anti-GRIK4 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Ca-permeable Kainate Receptor Pathway antibodies  Activation Of Ca-permeable Kainate Receptor Pathway Diagram
 Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies  Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Ionotropic Activity Of Kainate Receptors Pathway antibodies  Ionotropic Activity Of Kainate Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with anti-GRIK4 antibody

 Disease Name  Pubmed Publications
 Depressive Disorder Antibodies  >12 publications with GRIK4 and Depressive Disorder
 Nervous System Diseases Antibodies  >7 publications with GRIK4 and Nervous System Diseases
 Brain Diseases Antibodies  >4 publications with GRIK4 and Brain Diseases
 Learning Disorders Antibodies  >4 publications with GRIK4 and Learning Disorders
 Neurobehavioral Manifestations Antibodies  >3 publications with GRIK4 and Neurobehavioral Manifestations
 Disease Models, Animal Antibodies  >2 publications with GRIK4 and Disease Models, Animal
 Memory Disorders Antibodies  >2 publications with GRIK4 and Memory Disorders
 Cardiovascular Diseases Antibodies  >1 publications with GRIK4 and Cardiovascular Diseases
 Inflammation Antibodies  >1 publications with GRIK4 and Inflammation
 Cognition Disorders Antibodies  >1 publications with GRIK4 and Cognition Disorders

Organs/Tissues associated with anti-GRIK4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with GRIK4 and Brain
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