Rabbit Anti-UCMA Polyclonal Antibody – Cat# MBS150184

Western blot analysis of UCMA in SW1353 cell lysate with UCMA antibody at 2.5 μg/mL.

UCMA Antibody – Rabbit Polyclonal

Name: UCMA Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS150184
Price: 530 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150184

UCMA Antibody: UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of… More details

$530 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

UCMA, Polyclonal Antibody

Full Product Name

UCMA Antibody

Product Gene Name

anti-UCMA antibody

Product Synonym Names

UCMA Antibody: GRP, C10orf49, Unique cartilage matrix-associated protein, Gla-rich protein, Ucma-C

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Liquid; UCMA Antibody is supplied in PBS containing 0.02% sodium azide.

Purity/Purification

UCMA Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL (lot specific)

Preparation and Storage

UCMA antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
As with all antibodies care should be taken to avoid repeated freeze thaw cycles.
Antibodies should not be exposed to prolonged high temperatures.

Antibody/Peptide Pairs

UCMA peptide (MBS153198) is used for blocking the activity of UCMA antibody (MBS150184)

Molecular Weight

Predicted: 15 kDa
Observed: 19 kDa

3D Structure

ModBase 3D Structure for Q8WVF2

Homology

Predicted species reactivity based on immunogen sequence: Rat: (81%)

Immunogen

UCMA antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human UCMA.
The immunogen is located within the last 50 amino acids of UCMA.

Positive Control

1) Cat. No. MBS151599 - SW1353 Cell Lysate

Conjugate

Unconjugated

Applications Tested/Suitable for anti-UCMA antibody

ELISA, Western Blot (WB)

Application Notes for anti-UCMA antibody

UCMA antibody can be used for detection of UCMA by Western blot at 2.5 - 5 ug/mL.

Antibody validated: Western Blot in human samples.

All other applications and species not yet tested.
Optimal dilutions for each application to be determined by the researcher.

Other Notes

Small volumes of anti-UCMA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UCMA purchase

MBS150184 is an antibody targeting UCMA. Also known as UCMA Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UCMA. It may not necessarily be applicable to this product.

NCBI GI #

50400088

NCBI GeneID

221044

NCBI Accession #

NP_660357

UniProt Primary Accession #

Q8WVF2

UniProt Related Accession #

Q8WVF2

GenBank Nucleotide #

NM_145314.2

NCBI Official Full Name

unique cartilage matrix-associated protein isoform 1 preproprotein

NCBI Official Synonym Full Names

upper zone of growth plate and cartilage matrix associated

NCBI Official Symbol

UCMA

NCBI Official Synonym Symbols

GRP; C10orf49; GRP/UCMA

UniProt Protein Name

Unique cartilage matrix-associated protein

UniProt Synonym Protein Names

Gla-rich protein; GRP

Protein Family

Unique cartilage matrix-associated protein

UniProt Gene Name

UCMA

UniProt Synonym Gene Names

C10orf49; Ucma-C; GRP

UniProt Entry Name

UCMA_HUMAN

NCBI Protein Information

unique cartilage matrix-associated protein; Gla-rich protein

NCBI Summary for UCMA

This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

UniProt Comments for UCMA

UCMA: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. Belongs to the UCMA family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: proteinaceous extracellular matrix; extracellular space; perinuclear region of cytoplasm

Biological Process: negative regulation of osteoblast differentiation

Research Articles on UCMA

1. full exon resequencing of DNA samples from 17 chronic kidney disease patients (stage 5) and 121 healthy controls in a Swsedish population; the 138Thr > Ser polymorphism seems to be the only non-synonymous SNP found in the UCMA gene in a Swedish population

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-UCMA antibody

Disease Name	Pubmed Publications
Hypertrophy Antibodies	>1 publications with UCMA and Hypertrophy

Organs/Tissues associated with anti-UCMA antibody

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>3 publications with UCMA and Connective Tissue
Embryonic Tissue Antibodies	>3 publications with UCMA and Embryonic Tissue