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EI24 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150206

EI24 Antibody: The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor. EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER). It binds… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
EI24, Polyclonal Antibody
Full Product Name
EI24 Antibody
Product Gene Name
Product Synonym Names
EI24; EPG4; PIG8; TP53I8; p53-induced gene 8 protein; etoposide induced 2.4 mRNA
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
EI24 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least two isoforms of EI24 are known to exist; this antibody will only detect the larger isoform.
Preparation and Storage
EI24 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
EI24 peptide (MBS151813) is used for blocking the activity of EI24 antibody (MBS150206)
Molecular Weight
37,462 Da
OMIM
605170
3D Structure
ModBase 3D Structure for O14681
Conjugate
Unconjugated
Immunogen
EI24 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human EI24.
Buffer
EI24 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-EI24 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-EI24 antibody
EI24 antibody can be used for detection of EI24 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.

Western Blot (WB) of anti-EI24 antibody

Western blot analysis of EI24 in rat liver tissue lysate with EI24 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-EI24 Polyclonal Antibody – Cat# MBS150206

Immunohistochemistry (IHC) of anti-EI24 antibody

Immunohistochemistry of EI24 in rat liver tissue with EI24 antibody at 5 μg/mL.
Rabbit Anti-EI24 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150206

Other Notes

Small volumes of anti-EI24 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EI24 purchase

MBS150206 is an antibody targeting EI24. Also known as EI24 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EI24. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
etoposide-induced protein 2.4 homolog isoform 1
NCBI Official Synonym Full Names
etoposide induced 2.4
NCBI Official Symbol
EI24
NCBI Official Synonym Symbols
EPG4; PIG8; TP53I8
UniProt Protein Name
Etoposide-induced protein 2.4 homolog
UniProt Synonym Protein Names
p53-induced gene 8 protein
UniProt Gene Name
EI24
UniProt Synonym Gene Names
PIG8
UniProt Entry Name
EI24_HUMAN
NCBI Protein Information
etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein; tumor protein p53 inducible protein 8; ectopic P-granules autophagy protein 4 homolog

NCBI Summary for EI24

This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
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UniProt Comments for EI24

EI24: a p53-induced gene that appears to play a role in p53-mediated events. May activate apoptosis and reduce tumor invasiveness. Mutations in its gene have been associated with breast cancer.

Protein type: Membrane protein, multi-pass; Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; nuclear membrane; membrane; endoplasmic reticulum; cytoplasm; integral to membrane

Biological Process: response to drug; DNA damage response, signal transduction resulting in induction of apoptosis; apoptosis; autophagy; negative regulation of cell growth; neuromuscular process controlling balance
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EI24 antibody

 Reference Product  PubMed Publications
 BCL2L1 antibody  >3 publications with EI24 and BCL2L1

Pathways associated with anti-EI24 antibody

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