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TMEM59 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150213

TMEM59 Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TMEM59, Polyclonal Antibody
Full Product Name
TMEM59 Antibody
Product Gene Name
Product Synonym Names
TMEM59; C1orf8; HSPC001; C1orf8; UNQ169/PRO195; Transmembrane protein 59; Liver membrane-bound protein; transmembrane protein 59
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
TMEM59 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
TMEM59 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
TMEM59 peptide (MBS152926) is used for blocking the activity of TMEM59 antibody (MBS150213)
Molecular Weight
36,223 Da
3D Structure
ModBase 3D Structure for Q9BXS4
Conjugate
Unconjugated
Immunogen
TMEM59 antibody was raised against a 16 amino acid synthetic peptide near amino terminus of human TMEM59.
Buffer
TMEM59 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-TMEM59 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TMEM59 antibody
TMEM59 antibody can be used for detection of TMEM59 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-TMEM59 antibody

Western blot analysis of TMEM59 in human kidney tissue lysate with TMEM59 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-TMEM59 Polyclonal Antibody – Cat# MBS150213

Immunohistochemistry (IHC) of anti-TMEM59 antibody

Immunohistochemistry of TMEM59 in human kidney tissue with TMEM59 antibody at 2.5 μg/mL.
Rabbit Anti-TMEM59 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150213

Immunofluorescence (IF) of anti-TMEM59 antibody

Immunofluorescence of TMEM59 in human kidney tissue with TMEM59 antibody at 20 μg/mL.
Rabbit Anti-TMEM59 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150213

Other Notes

Small volumes of anti-TMEM59 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TMEM59 purchase

MBS150213 is an antibody targeting TMEM59. Also known as TMEM59 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TMEM59. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
transmembrane protein 59
NCBI Official Synonym Full Names
transmembrane protein 59
NCBI Official Symbol
TMEM59
NCBI Official Synonym Symbols
C1orf8; HSPC001
UniProt Protein Name
Transmembrane protein 59
UniProt Synonym Protein Names
Liver membrane-bound protein
Protein Family
UniProt Gene Name
TMEM59
UniProt Synonym Gene Names
C1orf8
UniProt Entry Name
TMM59_HUMAN
NCBI Protein Information
transmembrane protein 59; liver membrane-bound protein

NCBI Summary for TMEM59

This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
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UniProt Comments for TMEM59

TMEM59: Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. Belongs to the TMEM59 family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p32.3

Cellular Component: Golgi membrane; lysosome; Golgi trans cisterna; lysosomal membrane; late endosome membrane; late endosome; integral to membrane; plasma membrane; Golgi cis cisterna; Golgi medial cisterna

Molecular Function: protein binding; endopeptidase activity

Biological Process: autophagy; proteolysis; positive regulation of autophagy
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TMEM59 antibody

Organs/Tissues associated with anti-TMEM59 antibody

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