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CRIM2 (KCP) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150290

CRIM2 Antibody: CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CRIM2 (KCP), Polyclonal Antibody
Full Product Name
CRIM2 Antibody
Product Gene Name
Product Synonym Names
CRIM2; KCP1; CRIM2; NET67; KCP1; Cysteine-rich BMP regulator 2; CRIM-2; kielin/chordin-like protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
CRIM2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least two isoforms of CRIM2 are known to exist; this antibody will only detect the larger isoform. CRIM2 antibody is predicted to not cross-react with CRIM1.
Preparation and Storage
CRIM2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
CRIM2 peptide (MBS152877) is used for blocking the activity of CRIM2 antibody (MBS150290)
Molecular Weight
31,744 Da
OMIM
609344
3D Structure
ModBase 3D Structure for Q6ZWJ8
Conjugate
Unconjugated
Immunogen
CRIM2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human CRIM2.
Buffer
CRIM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-KCP antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-KCP antibody
CRIM2 antibody can be used for detection of CRIM2 by Western blot at 1 - 2 mug/mL.

Western Blot (WB) of anti-KCP antibody

Western blot analysis of CRIM2 in Jurkat cell lysate with CRIM2 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-KCP Polyclonal Antibody – Cat# MBS150290

Other Notes

Small volumes of anti-KCP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCP purchase

MBS150290 is an antibody targeting KCP. Also known as CRIM2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCP. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
kielin/chordin-like protein isoform 1
NCBI Official Synonym Full Names
kielin/chordin-like protein
NCBI Official Symbol
KCP
NCBI Official Synonym Symbols
KCP1; CRIM2; NET67
UniProt Protein Name
Kielin/chordin-like protein
UniProt Synonym Protein Names
Cysteine-rich BMP regulator 2; Cysteine-rich motor neuron 2 protein; CRIM-2; Kielin/chordin-like protein 1; KCP-1
UniProt Gene Name
KCP
UniProt Synonym Gene Names
CRIM2; KCP1; CRIM-2; KCP-1
UniProt Entry Name
KCP_HUMAN
NCBI Protein Information
kielin/chordin-like protein; KCP-1; CRIM-2; cysteine-rich BMP regulator 2; kielin/chordin-like protein 1; cysteine-rich motor neuron 2 protein; cysteine rich BMP regulator 2 (chordin-like)

UniProt Comments for KCP

CRIM2: Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q32.1

Cellular Component: extracellular region
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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