• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TNFRSF12A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150342

Fn14 Antibody: TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis. These pathways are mediated by the binding of TWEAK by… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Fn14 (TNFRSF12A), Polyclonal Antibody
Full Product Name
Fn14 Antibody
Product Gene Name
anti-TNFRSF12A antibody
Product Synonym Names
Fn14; FN14; CD266; TWEAKR; FN14; Tumor necrosis factor receptor superfamily member 12A; Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; tumor necrosis factor receptor superfamily, member 12A
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Fn14 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
Fn14 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight
10,191 Da
OMIM
605914
3D Structure
ModBase 3D Structure for Q9NP84
Conjugate
Unconjugated
Immunogen
Fn14 antibody was raised against a human IgG1 Fc-tagged Fn14 protein.
Buffer
Fn14 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-TNFRSF12A antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TNFRSF12A antibody
Fn14 antibody can be used for the detection of Fn14 by Western blot at 2 - 4 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-TNFRSF12A antibody

Western blot analysis of Fn14 in HepG2 cells with Fn14 antibody at (A) 2 and (B) 4 μg/mL.
Rabbit Anti-TNFRSF12A Polyclonal Antibody – Cat# MBS150342

Immunohistochemistry (IHC) of anti-TNFRSF12A antibody

Immunohistochemistry of Fn14 in human liver tissue with Fn14 antibody at 2.5 μg/mL.
Rabbit Anti-TNFRSF12A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150342

Immunofluorescence (IF) of anti-TNFRSF12A antibody

Immunofluorescence of Fn14 in Human Liver cells with Fn14 antibody at 20 μg/mL.
Rabbit Anti-TNFRSF12A Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150342

Other Notes

Small volumes of anti-TNFRSF12A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF12A purchase

MBS150342 is an antibody targeting TNFRSF12A. Also known as Fn14 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF12A. It may not necessarily be applicable to this product.

NCBI GI #
7706186
NCBI GeneID
51330
NCBI Accession #
NP_057723
UniProt Primary Accession #
Q9NP84
UniProt Secondary Accession #
Q9HCS0; D3DUA6
UniProt Related Accession #
Q9NP84
GenBank Nucleotide #
NM_016639.2
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 12A
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 12A
NCBI Official Symbol
TNFRSF12A
NCBI Official Synonym Symbols
FN14; CD266; TWEAKR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 12A
UniProt Synonym Protein Names
Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD_antigen: CD266
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF12A
UniProt Synonym Gene Names
FN14; FGF-inducible 14; TweakR
UniProt Entry Name
TNR12_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 12A; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14

UniProt Comments for TNFRSF12A

TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell development/differentiation; Receptor, misc.

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: ruffle; cell surface; integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: positive regulation of apoptosis; substrate-bound cell migration, cell attachment to substrate; positive regulation of axon extension; angiogenesis; regulation of angiogenesis
Show more

Research Articles on TNFRSF12A

1. results define one upstream mechanism, via FN14 signaling, through which the NFkappaB pathway contributes to prostate cancer metastasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNFRSF12A antibody

 Reference Product  PubMed Publications
 TNFSF12 antibody  >5 publications with TNFRSF12A and TNFSF12
 TNFRSF25 antibody  >1 publications with TNFRSF12A and TNFRSF25

Pathways associated with anti-TNFRSF12A antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 TWEAK Signaling Pathway antibodies  TWEAK Signaling Pathway Diagram

Diseases associated with anti-TNFRSF12A antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >13 publications with TNFRSF12A and Necrosis
 Inflammation Antibodies  >9 publications with TNFRSF12A and Inflammation
 Neoplasms, Experimental Antibodies  >4 publications with TNFRSF12A and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >3 publications with TNFRSF12A and Cardiovascular Diseases
 Heart Diseases Antibodies  >2 publications with TNFRSF12A and Heart Diseases
 Lung Neoplasms Antibodies  >2 publications with TNFRSF12A and Lung Neoplasms
 Disease Models, Animal Antibodies  >2 publications with TNFRSF12A and Disease Models, Animal
 Adenocarcinoma Antibodies  >2 publications with TNFRSF12A and Adenocarcinoma
 Lung Diseases Antibodies  >2 publications with TNFRSF12A and Lung Diseases
 Breast Neoplasms Antibodies  >1 publications with TNFRSF12A and Breast Neoplasms

Organs/Tissues associated with anti-TNFRSF12A antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >7 publications with TNFRSF12A and Vascular
 Lung Antibodies  >7 publications with TNFRSF12A and Lung
 Muscle Antibodies  >5 publications with TNFRSF12A and Muscle
 Blood Antibodies  >4 publications with TNFRSF12A and Blood
 Eye Antibodies  >3 publications with TNFRSF12A and Eye
 Kidney Antibodies  >2 publications with TNFRSF12A and Kidney
 Heart Antibodies  >2 publications with TNFRSF12A and Heart
 Bone Antibodies  >2 publications with TNFRSF12A and Bone
 Brain Antibodies  >1 publications with TNFRSF12A and Brain
 Intestine Antibodies  >1 publications with TNFRSF12A and Intestine
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000