• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

SCO1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150350

SCO2 Antibody: Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SCO2 (SCO1), Polyclonal Antibody
Full Product Name
SCO2 Antibody
Product Gene Name
anti-SCO1 antibody
Product Synonym Names
SCO2; SCOD1; Protein SCO2 homolog; mitochondrial; SCO cytochrome oxidase deficient homolog 1 (yeast)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
SCO2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
SCO2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
SCO2 peptide (MBS152797) is used for blocking the activity of SCO2 antibody (MBS150350)
Molecular Weight
29,810 Da
OMIM
phenotype 608908
3D Structure
ModBase 3D Structure for O43819
Conjugate
Unconjugated
Immunogen
SCO2 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human SCO2.
Buffer
SCO2 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-SCO1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-SCO1 antibody
SCO2 antibody can be used for detection of SCO2 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-SCO1 antibody

Western blot analysis of SCO2 in HL60 cell lysate lysate with SCO2 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-SCO1 Polyclonal Antibody – Cat# MBS150350

Immunohistochemistry (IHC) of anti-SCO1 antibody

Immunohistochemistry of SCO2 in human liver tissue with SCO2 antibody at 2.5 μg/mL.
Rabbit Anti-SCO1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150350

Immunofluorescence (IF) of anti-SCO1 antibody

Immunofluorescence of SCO2 in Human Liver tissue with SCO2 antibody at 20 μg/mL.
Rabbit Anti-SCO1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150350

Other Notes

Small volumes of anti-SCO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SCO1 purchase

MBS150350 is an antibody targeting SCO1. Also known as SCO2 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SCO1. It may not necessarily be applicable to this product.

NCBI GI #
8134662
NCBI GeneID
9997
NCBI Accession #
O43819.3
UniProt Primary Accession #
O43819
UniProt Secondary Accession #
Q3T1B5; Q9UK87
UniProt Related Accession #
O43819
NCBI Official Full Name
Protein SCO2 homolog, mitochondrial
NCBI Official Synonym Full Names
SCO2 cytochrome c oxidase assembly protein
NCBI Official Symbol
SCO2
NCBI Official Synonym Symbols
MYP6; SCO1L; CEMCOX1
UniProt Protein Name
Protein SCO2 homolog, mitochondrial
Protein Family
Protein
UniProt Gene Name
SCO2
UniProt Entry Name
SCO2_HUMAN
NCBI Protein Information
protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2

NCBI Summary for SCO1

Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. [provided by RefSeq, Oct 2014]
Show more

UniProt Comments for SCO1

SCO2: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Belongs to the SCO1/2 family.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: nucleoplasm; myofibril; mitochondrion; mitochondrial inner membrane

Molecular Function: copper ion binding

Biological Process: cellular copper ion homeostasis; eye development; in utero embryonic development; respiratory chain complex IV assembly; response to activity; muscle system process; copper ion transport

Disease: Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency 1; Myopia 6
Show more

Research Articles on SCO1

1. COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SCO1 antibody

 Reference Product  PubMed Publications
 COX17 antibody  >18 publications with SCO1 and COX17
 SURF1 antibody  >16 publications with SCO1 and SURF1
 COX10 antibody  >14 publications with SCO1 and COX10
 COX11 antibody  >10 publications with SCO1 and COX11
 TP53 antibody  >10 publications with SCO1 and TP53
 COX15 antibody  >6 publications with SCO1 and COX15
 TYMP antibody  >2 publications with SCO1 and TYMP

Pathways associated with anti-SCO1 antibody

 Products by Pathway  Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Orphan Transporters Pathway antibodies  Orphan Transporters Pathway Diagram
 Respiratory Electron Transport Pathway antibodies  Respiratory Electron Transport Pathway Diagram
 Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway antibodies  Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway Diagram
 The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway antibodies  The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Pyrimidine Deoxyribonucleosides Degradation Pathway antibodies  Pyrimidine Deoxyribonucleosides Degradation Pathway Diagram
 Pyrimidine Deoxyribonucleosides Degradation Pathway antibodies  Pyrimidine Deoxyribonucleosides Degradation Pathway Diagram

Diseases associated with anti-SCO1 antibody

 Disease Name  Pubmed Publications
 Cytochrome-c Oxidase Deficiency Antibodies  >58 publications with SCO1 and Cytochrome-c Oxidase Deficiency
 Nervous System Diseases Antibodies  >39 publications with SCO1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >38 publications with SCO1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >32 publications with SCO1 and Heart Diseases
 Cardiomyopathies Antibodies  >21 publications with SCO1 and Cardiomyopathies
 Cardiomyopathy, Hypertrophic Antibodies  >19 publications with SCO1 and Cardiomyopathy, Hypertrophic
 Cardioencephalomyopathy, Fatal Infantile, due to Cytochrome C Oxidase Deficiency Antibodies  >12 publications with SCO1 and Cardioencephalomyopathy, Fatal Infantile, due to Cytochrome C Oxidase Deficiency
 Congenital Abnormalities Antibodies  >10 publications with SCO1 and Congenital Abnormalities
 Heart Failure Antibodies  >8 publications with SCO1 and Heart Failure
 Mitochondrial Encephalomyopathies Antibodies  >7 publications with SCO1 and Mitochondrial Encephalomyopathies

Organs/Tissues associated with anti-SCO1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >56 publications with SCO1 and Blood
 Muscle Antibodies  >44 publications with SCO1 and Muscle
 Brain Antibodies  >43 publications with SCO1 and Brain
 Liver Antibodies  >15 publications with SCO1 and Liver
 Lung Antibodies  >9 publications with SCO1 and Lung
 Skin Antibodies  >5 publications with SCO1 and Skin
 Kidney Antibodies  >2 publications with SCO1 and Kidney
 Ganglia Antibodies  >2 publications with SCO1 and Ganglia
 Eye Antibodies  >1 publications with SCO1 and Eye
 Intestine Antibodies  >1 publications with SCO1 and Intestine
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000