GRIK5 Antibody – Rabbit Polyclonal

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GluR KA2: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; endoplasmic reticulum; dendrite; postsynaptic density; plasma membrane; terminal button; perikaryon; cell junction

Molecular Function: identical protein binding; kainate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; SH3 domain binding; PDZ domain binding

Biological Process: synaptic transmission, glutamatergic; synaptic transmission; ionotropic glutamate receptor signaling pathway; regulation of synaptic vesicle fusion to presynaptic membrane; positive regulation of neuron apoptosis; regulation of excitatory postsynaptic membrane potential; receptor clustering; protein retention in ER; establishment of cellular localization