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IRF2BP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150464

IRF2BP2 Antibody: IRF2BP2, like the related protein IRF2BP1, is a co-repressor that interacts specifically with the C-terminal repression domain of Interferon Regulatory Factor 2 (IRF2). IRF2BP2 is a direct target gene of p53 and is involved in cell survival… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
IRF2BP2, Polyclonal Antibody
Full Product Name
IRF2BP2 Antibody
Product Gene Name
Product Synonym Names
IRF2BP2; Interferon regulatory factor 2-binding protein 2; IRF-2-binding protein 2; interferon regulatory factor 2 binding protein 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid; IRF2BP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purity/Purification
IRF2BP2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least two isoforms of IRF2BP2 are known to exist; this antibody will detect both. This antibody is predicted to not cross-react with any FOXD4 protein family members.
Preparation and Storage
IRF2BP2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
IRF2BP2 peptide (MBS152370) is used for blocking the activity of IRF2BP2 antibody (MBS150464)
OMIM
615332
3D Structure
ModBase 3D Structure for Q7Z5L9
Conjugate
Unconjugated
Immunogen
IRF2BP2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human IRF2BP2.
The immunogen is located within amino acids 440-490 of IRF2BP2.
Positive Control
1) Cat No. MBS151603 -HeLa Cell Lysate
2) Cat No. MBS154228 - A-20 Cell Slide.
Applications Tested/Suitable for anti-IRF2BP2 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-IRF2BP2 antibody
IRF2BP2 antibody can be used for detection of IRF2BP2 by Western blot at 1 ug/mL. Antibody can also be used for immunocytochemistry starting at 2.5 ug/mL.
Antibody validated: Western Blot in human samples and immunohistochemistryin mouse samples. All other applications and species not yet tested.

Western Blot (WB) of anti-IRF2BP2 antibody

Rabbit Anti-IRF2BP2 Polyclonal Antibody – Cat# MBS150464

Immunocytochemistry (IHC) of anti-IRF2BP2 antibody

Immunocytochemistry of IRF2BP2 in A20 cells with IRF2BP2 antibody at 2.5 μg/mL.
Rabbit Anti-IRF2BP2 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS150464

Other Notes

Small volumes of anti-IRF2BP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IRF2BP2 purchase

MBS150464 is an antibody targeting IRF2BP2. Also known as IRF2BP2 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IRF2BP2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interferon regulatory factor 2-binding protein 2 isoform A
NCBI Official Synonym Full Names
interferon regulatory factor 2 binding protein 2
NCBI Official Symbol
IRF2BP2
UniProt Protein Name
Interferon regulatory factor 2-binding protein 2
UniProt Gene Name
IRF2BP2
UniProt Synonym Gene Names
IRF-2-binding protein 2; IRF-2BP2
UniProt Entry Name
I2BP2_HUMAN
NCBI Protein Information
interferon regulatory factor 2-binding protein 2; IRF-2-binding protein 2

NCBI Summary for IRF2BP2

This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for IRF2BP2

IRF2BP2: Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle. Belongs to the IRF2BP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q42.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: metal ion binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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