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VAMP7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150467

VAMP7 Antibody: VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as… More details

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Product Overview

Online Datasheet in PDF
Product Name
VAMP7, Polyclonal Antibody
Full Product Name
VAMP7 Antibody
Product Gene Name
anti-VAMP7 antibody
Product Synonym Names
VAMP7; SYBL1; TIVAMP; VAMP-7; TI-VAMP; SYBL1; Vesicle-associated membrane protein 7; Synaptobrevin-like protein 1; vesicle-associated membrane protein 7
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
VAMP7 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least three isoforms of VAMP7 are known to exist; this antibody will detect the two longest isoforms. This antibody is predicted to not cross-react with other Ras-related proteins.
Preparation and Storage
VAMP7 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
VAMP7 peptide (MBS151807) is used for blocking the activity of VAMP7 antibody (MBS150467)
Molecular Weight
20,121 Da
OMIM
300053
3D Structure
ModBase 3D Structure for P51809
Conjugate
Unconjugated
Immunogen
VAMP7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human VAMP7.
Buffer
VAMP7 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-VAMP7 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-VAMP7 antibody
VAMP7 antibody can be used for detection of VAMP7 by Western blot at 1 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-VAMP7 antibody

Western blot analysis of VAMP7 in mouse lung tissue lysate with VAMP7 antibody at (A) 0.5 and (B) 1 μg/mL.
Rabbit Anti-VAMP7 Polyclonal Antibody – Cat# MBS150467

Immunofluorescence (IF) of anti-VAMP7 antibody

Immunofluorescence of VAMP7 in human lung tissue with VAMP7 antibody at 20 μg/mL.
Rabbit Anti-VAMP7 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150467

Other Notes

Small volumes of anti-VAMP7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VAMP7 purchase

MBS150467 is an antibody targeting VAMP7. Also known as VAMP7 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for VAMP7. It may not necessarily be applicable to this product.

NCBI GI #
297747292
NCBI GeneID
6845
NCBI Accession #
NP_001172112
UniProt Primary Accession #
P51809
UniProt Secondary Accession #
Q53GY7; Q7Z409; Q9H4A7
UniProt Related Accession #
P51809
GenBank Nucleotide #
NM_001185183.1
NCBI Official Full Name
vesicle-associated membrane protein 7 isoform 3
NCBI Official Synonym Full Names
vesicle-associated membrane protein 7
NCBI Official Symbol
VAMP7
NCBI Official Synonym Symbols
SYBL1; TIVAMP; VAMP-7; TI-VAMP
UniProt Protein Name
Vesicle-associated membrane protein 7
UniProt Synonym Protein Names
Synaptobrevin-like protein 1; Tetanus-insensitive VAMP; Ti-VAMP
Protein Family
Vesicle-associated membrane protein
UniProt Gene Name
VAMP7
UniProt Synonym Gene Names
SYBL1; VAMP-7; Ti-VAMP
UniProt Entry Name
VAMP7_HUMAN
NCBI Protein Information
vesicle-associated membrane protein 7; synaptobrevin-like 1; tetanus-insensitive VAMP; synaptobrevin-like protein 1; tetanus neurotoxin-insensitive VAMP

NCBI Summary for VAMP7

This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
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UniProt Comments for VAMP7

VAMP7: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28 and Yq12

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; neuron projection; cell surface; intracellular membrane-bound organelle; lysosomal membrane; late endosome membrane; secretory granule membrane; integral to membrane; pseudopodium; phagocytic vesicle; trans-Golgi network; secretory granule; SNARE complex; phagocytic vesicle membrane; membrane; apical part of cell; perinuclear region of cytoplasm; lamellipodium; cytoplasm; plasma membrane; synapse; cell junction

Molecular Function: SNAP receptor activity; protein binding; SNARE binding; syntaxin binding

Biological Process: ER to Golgi vesicle-mediated transport; exocytosis; natural killer cell degranulation; autophagic vacuole fusion; neutrophil degranulation; endocytosis; vesicle fusion with Golgi apparatus; calcium ion-dependent exocytosis; vesicle fusion; vesicle-mediated transport; Golgi to plasma membrane protein transport; endosome to lysosome transport; eosinophil degranulation; post-Golgi vesicle-mediated transport; triacylglycerol transport; phagocytosis, engulfment
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Research Articles on VAMP7

1. increased gene dosage of VAMP7, and thus higher expression levels of its protein product, enhances estrogen receptor action in male genitourinary tissues

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VAMP7 antibody

 Reference Product  PubMed Publications
 SNAP23 antibody  >13 publications with VAMP7 and SNAP23
 VTI1A antibody  >10 publications with VAMP7 and VTI1A
 BET1 antibody  >1 publications with VAMP7 and BET1
 STX16 antibody  >1 publications with VAMP7 and STX16
 AGFG1 antibody  >1 publications with VAMP7 and AGFG1
 STX7 antibody  >1 publications with VAMP7 and STX7

Pathways associated with anti-VAMP7 antibody

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Lysosome Vesicle Biogenesis Pathway antibodies  Lysosome Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 SNARE Interactions In Vesicular Transport Pathway antibodies  SNARE Interactions In Vesicular Transport Pathway Diagram
 SNARE Interactions In Vesicular Transport Pathway antibodies  SNARE Interactions In Vesicular Transport Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram

Diseases associated with anti-VAMP7 antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >6 publications with VAMP7 and Death
 Disease Models, Animal Antibodies  >2 publications with VAMP7 and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with VAMP7 and Breast Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with VAMP7 and Congenital Abnormalities
 Chromosome Aberrations Antibodies  >1 publications with VAMP7 and Chromosome Aberrations
 Cardiovascular Diseases Antibodies  >1 publications with VAMP7 and Cardiovascular Diseases
 Neurodegenerative Diseases Antibodies  >1 publications with VAMP7 and Neurodegenerative Diseases
 Inflammation Antibodies  >1 publications with VAMP7 and Inflammation
 Necrosis Antibodies  >1 publications with VAMP7 and Necrosis

Organs/Tissues associated with anti-VAMP7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with VAMP7 and Brain
 Blood Antibodies  >13 publications with VAMP7 and Blood
 Kidney Antibodies  >8 publications with VAMP7 and Kidney
 Intestine Antibodies  >6 publications with VAMP7 and Intestine
 Liver Antibodies  >3 publications with VAMP7 and Liver
 Muscle Antibodies  >3 publications with VAMP7 and Muscle
 Stomach Antibodies  >2 publications with VAMP7 and Stomach
 Bone Antibodies  >2 publications with VAMP7 and Bone
 Eye Antibodies  >2 publications with VAMP7 and Eye
 Ovary Antibodies  >1 publications with VAMP7 and Ovary
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