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IL1RL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150471

ST2 Antibody: ST2 is a member of a superfamily containing the interleukin-1 receptor and the Toll-like receptors (TLRs). The TLRs are signaling molecules that recognize different microbial products during infection and serve as an important link between the… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ST2 (Il1rl1), Polyclonal Antibody
Full Product Name
ST2 Antibody
Product Gene Name
anti-Il1rl1 antibody
Product Synonym Names
ST2; T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1; Ste2; Interleukin-1 receptor-like 1; Lymphocyte antigen 84; interleukin 1 receptor-like 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid; T2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purity/Purification
ST2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
ST2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
ST2 peptide (MBS152624) is used for blocking the activity of ST2 antibody (MBS150471)
3D Structure
ModBase 3D Structure for P14719
Conjugate
Unconjugated
Immunogen
ST2 antibody was raised against a synthetic peptide corresponding to 16 amino acids at the amino-terminus of mouse ST2.
This peptide is common to all three known ST2 isoforms.
The immunogen is located within amino acids 40-90 of ST2.
Homology
Predicted species reactivity based in immunogen sequence: Rat (88%)
Applications Tested/Suitable for anti-Il1rl1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunofluorescence (IF)

Western Blot (WB) of anti-Il1rl1 antibody

ST2 Antibody 1
Western blot analysis of ST2 in 293 cell lysate with ST2 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-IL1RL1 Polyclonal Antibody – Cat# MBS150471

Immunohistochemistry (IHC) of anti-Il1rl1 antibody

ST2 Antibody 2
Immunohistochemistry of ST2 in human liver tissue with ST2 antibody at 5 μg/mL.
Rabbit Anti-IL1RL1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150471

Immunofluorescence (IF) of anti-Il1rl1 antibody

ST2 Antibody 3
Immunofluorescence of ST2 in Mouse Kidney cells with ST2 antibody at 20 μg/mL.
Rabbit Anti-IL1RL1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150471

Immunohistochemistry (IHC) of anti-Il1rl1 antibody

ST2 Antibody 4
Immunohistochemistry of ST2 in mouse kidney tissue with ST2 antibody at 2 μg/mL.
Rabbit Anti-IL1RL1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150471

Other Notes

Small volumes of anti-Il1rl1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Il1rl1 purchase

MBS150471 is an antibody targeting Il1rl1. Also known as ST2 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Il1rl1. It may not necessarily be applicable to this product.

NCBI GI #
286101
NCBI GeneID
17082
NCBI Accession #
BAA02854
UniProt Primary Accession #
P14719
UniProt Secondary Accession #
Q05208
UniProt Related Accession #
P14719
NCBI Official Full Name
ST2L protein
NCBI Official Synonym Full Names
interleukin 1 receptor-like 1
NCBI Official Symbol
Il1rl1
NCBI Official Synonym Symbols
T1; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1
UniProt Protein Name
Interleukin-1 receptor-like 1
UniProt Synonym Protein Names
Lymphocyte antigen 84; Protein ST2; Protein T1
Protein Family
Interleukin-1 receptor
UniProt Gene Name
Il1rl1
UniProt Synonym Gene Names
Ly84; St2; Ste2
UniProt Entry Name
ILRL1_MOUSE
NCBI Protein Information
interleukin-1 receptor-like 1; lymphocyte antigen 84

UniProt Comments for Il1rl1

IL1RL1: receptor for IL33. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of ERK1 and/or ERK2, p38-alpha, and JNK1. Apparently promotes the activation and differentiation of T-helper 2 cells. Belongs to the interleukin-1 receptor family. Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Three isoforms of the human protein are produced by alternative splicing. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; membrane; integral to membrane; plasma membrane; extracellular region; external side of plasma membrane

Molecular Function: interleukin-1 receptor activity

Biological Process: negative regulation of cell proliferation; negative regulation of T-helper 1 type immune response; negative regulation of interferon-gamma production; negative regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response
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Research Articles on Il1rl1

1. ST2 does not impair the establishment of adult L. sigmodontis worms, but is important for the splenic clearance of microfilariae from peripheral blood.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Il1rl1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >172 publications with Il1rl1 and Inflammation
 Cardiovascular Diseases Antibodies  >120 publications with Il1rl1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >103 publications with Il1rl1 and Heart Diseases
 Lung Diseases Antibodies  >92 publications with Il1rl1 and Lung Diseases
 Asthma Antibodies  >84 publications with Il1rl1 and Asthma
 Necrosis Antibodies  >46 publications with Il1rl1 and Necrosis
 Disease Models, Animal Antibodies  >40 publications with Il1rl1 and Disease Models, Animal
 Fibrosis Antibodies  >20 publications with Il1rl1 and Fibrosis
 Pneumonia Antibodies  >14 publications with Il1rl1 and Pneumonia
 Hypertension Antibodies  >13 publications with Il1rl1 and Hypertension

Organs/Tissues associated with anti-Il1rl1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >304 publications with Il1rl1 and Blood
 Lung Antibodies  >70 publications with Il1rl1 and Lung
 Bone Marrow Antibodies  >34 publications with Il1rl1 and Bone Marrow
 Skin Antibodies  >23 publications with Il1rl1 and Skin
 Spleen Antibodies  >19 publications with Il1rl1 and Spleen
 Joint Antibodies  >12 publications with Il1rl1 and Joint
 Intestine Antibodies  >11 publications with Il1rl1 and Intestine
 Eye Antibodies  >10 publications with Il1rl1 and Eye
 Connective Tissue Antibodies  >8 publications with Il1rl1 and Connective Tissue
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