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NGFRAP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150522

NADE Antibody: The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NADE (NGFRAP1), Polyclonal Antibody
Full Product Name
NADE Antibody
Product Gene Name
anti-NGFRAP1 antibody
Product Synonym Names
NADE; Bex; BEX3; NADE; HGR74; DXS6984E; Protein BEX3; Brain-expressed X-linked protein 3; nerve growth factor receptor (TNFRSF16) associated protein 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
NADE Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
NADE antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
NADE peptide (MBS152157) is used for blocking the activity of NADE antibody (MBS150522)
Molecular Weight
11,762 Da
OMIM
300361
3D Structure
ModBase 3D Structure for Q00994
Conjugate
Unconjugated
Immunogen
NADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE.
Buffer
NADE Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-NGFRAP1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-NGFRAP1 antibody
NADE antibody can be used for detection of NADE by Western blot at 1 mug/mL. Despite its predicted molecular weight, NADE migrates at ~23 kDa in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 2 mug/mL.

Western Blot (WB) of anti-NGFRAP1 antibody

Western blot analysis of NADE in Human brain cell lysates with NADE antibody at 1 μg/mL in the presence (A) or absence (B) of blocking peptide.
Rabbit Anti-NGFRAP1 Polyclonal Antibody – Cat# MBS150522

Immunohistochemistry (IHC) of anti-NGFRAP1 antibody

Immunohistochemistry of NADE in human brain tissue with NADE antibody at 2 μg/mL.
Rabbit Anti-NGFRAP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150522

Other Notes

Small volumes of anti-NGFRAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NGFRAP1 purchase

MBS150522 is an antibody targeting NGFRAP1. Also known as NADE Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NGFRAP1. It may not necessarily be applicable to this product.

NCBI GI #
46094060
NCBI GeneID
27018
NCBI Accession #
NP_996798
UniProt Primary Accession #
Q00994
UniProt Secondary Accession #
Q5JQT4; Q5JQT5; B2RD17; D3DXA3
UniProt Related Accession #
Q00994
GenBank Nucleotide #
NM_206915.2
NCBI Official Full Name
protein BEX3 isoform b
NCBI Official Synonym Full Names
nerve growth factor receptor (TNFRSF16) associated protein 1
NCBI Official Symbol
NGFRAP1
NCBI Official Synonym Symbols
Bex; BEX3; NADE; HGR74; DXS6984E
UniProt Protein Name
Protein BEX3
UniProt Synonym Protein Names
Brain-expressed X-linked protein 3; Nerve growth factor receptor-associated protein 1; Ovarian granulosa cell 13.0 kDa protein HGR74; p75NTR-associated cell death executor
UniProt Gene Name
NGFRAP1
UniProt Synonym Gene Names
BEX3; DXS6984E; NADE
UniProt Entry Name
BEX3_HUMAN
NCBI Protein Information
protein BEX3; brain-expressed X-linked protein 3; p75NTR-associated cell death executor; ovarian granulosa cell 13.0 kDa protein HGR74

UniProt Comments for NGFRAP1

NGFRAP1: May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. May play an important role in the pathogenesis of neurogenetic diseases. Belongs to the BEX family.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: Xq22.2

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; metal ion binding; death receptor binding; caspase activator activity

Biological Process: caspase activation; nerve growth factor receptor signaling pathway; induction of apoptosis via death domain receptors; multicellular organismal development; regulation of caspase activity
Show more

Research Articles on NGFRAP1

1. Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NGFRAP1 antibody

 Reference Product  PubMed Publications
 CASP3 antibody  >2 publications with NGFRAP1 and CASP3
 YWHAQ antibody  >1 publications with NGFRAP1 and YWHAQ
 YWHAE antibody  >1 publications with NGFRAP1 and YWHAE
 NGFR antibody  >1 publications with NGFRAP1 and NGFR

Pathways associated with anti-NGFRAP1 antibody

 Products by Pathway  Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 NADE Modulates Death Signalling Pathway antibodies  NADE Modulates Death Signalling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
 P75 NTR Receptor-mediated Signalling Pathway antibodies  P75 NTR Receptor-mediated Signalling Pathway Diagram
 P75(NTR)-mediated Signaling Pathway antibodies  P75(NTR)-mediated Signaling Pathway Diagram

Diseases associated with anti-NGFRAP1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with NGFRAP1 and Nervous System Diseases
 Necrosis Antibodies  >5 publications with NGFRAP1 and Necrosis
 Congenital Abnormalities Antibodies  >1 publications with NGFRAP1 and Congenital Abnormalities
 Neoplasms, Experimental Antibodies  >1 publications with NGFRAP1 and Neoplasms, Experimental
 Seizures Antibodies  >1 publications with NGFRAP1 and Seizures
 Nerve Degeneration Antibodies  >1 publications with NGFRAP1 and Nerve Degeneration
 Breast Neoplasms Antibodies  >1 publications with NGFRAP1 and Breast Neoplasms
 Inflammation Antibodies  >1 publications with NGFRAP1 and Inflammation

Organs/Tissues associated with anti-NGFRAP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >18 publications with NGFRAP1 and Nerve
 Brain Antibodies  >13 publications with NGFRAP1 and Brain
 Muscle Antibodies  >2 publications with NGFRAP1 and Muscle
 Kidney Antibodies  >2 publications with NGFRAP1 and Kidney
 Connective Tissue Antibodies  >1 publications with NGFRAP1 and Connective Tissue
 Ovary Antibodies  >1 publications with NGFRAP1 and Ovary
 Eye Antibodies  >1 publications with NGFRAP1 and Eye
 Testis Antibodies  >1 publications with NGFRAP1 and Testis
 Skin Antibodies  >1 publications with NGFRAP1 and Skin
 Prostate Antibodies  >1 publications with NGFRAP1 and Prostate
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