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OTUD5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150538

OTUD5 Antibody: OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
OTUD5, Polyclonal Antibody
Full Product Name
OTUD5 Antibody
Product Gene Name
Product Synonym Names
OTUD5; DUBA; OTU domain-containing protein 5; Deubiquitinating enzyme A; DUBA; OTU domain containing 5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
OTUD5 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
OTUD5 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
OTUD5 peptide (MBS152570) is used for blocking the activity of OTUD5 antibody (MBS150538)
Molecular Weight
60,210 Da
OMIM
300713
3D Structure
ModBase 3D Structure for Q96G74
Conjugate
Unconjugated
Immunogen
OTUD5 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human OTUD5.
Buffer
OTUD5 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-OTUD5 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-OTUD5 antibody
OTUD5 antibody can be used for detection of OTUD5 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-OTUD5 antibody

Western blot analysis of OTUD5 in human kidney lysate with OTUD5 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-OTUD5 Polyclonal Antibody – Cat# MBS150538

Immunohistochemistry (IHC) of anti-OTUD5 antibody

Immunohistochemistry of OTUD5 in mouse kidney tissue with OTUD5 antibody at 2.5 μg/mL.
Rabbit Anti-OTUD5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150538

Immunofluorescence (IF) of anti-OTUD5 antibody

Immunofluorescence of OTUD5 in Human Kidney cells with OTUD5 antibody at 20 μg/mL.
Rabbit Anti-OTUD5 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150538

Other Notes

Small volumes of anti-OTUD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OTUD5 purchase

MBS150538 is an antibody targeting OTUD5. Also known as OTUD5 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OTUD5. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
OTU domain containing 5, isoform CRA_b
NCBI Official Synonym Full Names
OTU deubiquitinase 5
NCBI Official Symbol
OTUD5
NCBI Official Synonym Symbols
DUBA
UniProt Protein Name
OTU domain-containing protein 5
UniProt Synonym Protein Names
Deubiquitinating enzyme A; DUBA
UniProt Gene Name
OTUD5
UniProt Synonym Gene Names
DUBA
UniProt Entry Name
OTUD5_HUMAN
NCBI Protein Information
OTU domain-containing protein 5; OTU domain containing 5; deubiquinating enzyme A; deubiquitinating enzyme A

NCBI Summary for OTUD5

This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
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UniProt Comments for OTUD5

OTUD5: a protein of unknown function. Contains a OTU-like cysteine protease domain.

Protein type: EC 3.4.19.12; Protease; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: cytosol

Molecular Function: ubiquitin-specific protease activity

Biological Process: innate immune response; response to lipopolysaccharide; proteolysis; negative regulation of interferon type I production
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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