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CADPS2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150554

MBS150554 is an antibody targeting CADPS2. Also known as CAPS2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CAPS2 (CADPS2), Polyclonal Antibody
Full Product Name
CAPS2 Antibody
Product Gene Name
anti-CADPS2 antibody
Product Synonym Names
CAPS2; CAPS2; KIAA1591; Calcium-dependent secretion activator 2; Calcium-dependent activator protein for secretion 2; CAPS-2; Ca++-dependent secretion activator 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid; CAPS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purity/Purification
CAPS2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
Multiple isoforms of CAPS2 are known to exist.
This CAPS2 antibody is predicted to be specific to CAPS2 and not recognize CAPS1.
Preparation and Storage
CAPS2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
CAPS2 peptide (MBS152077) is used for blocking the activity of CAPS2 antibody (MBS150554)
Molecular Weight
Predicted Molecular Weight: 138, 145 kDa
Observed Molecular Weight: 150 kDa
OMIM
609978
3D Structure
ModBase 3D Structure for Q86UW7
Immunogen
CAPS2 antibody was raised against a 19 amino acid synthetic peptide near the center of the human CAPS2. The immunogen is located within amino acids 510-560 of CAPS2.
Applications Tested/Suitable for anti-CADPS2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry-paraffin (IHC-p), Immunofluorescence (IF)
Application Notes for anti-CADPS2 antibody
Optimal dilutions for each application to be determined by the researcher.
The information provided is a guidline for product use. This product is for research use only.

Western Blot (WB) of anti-CADPS2 antibody

Western blot analysis of CAPS2 in human brain tissue lysate with CAPS2 antibody at (A) 0.5 and (B) 1 μg/mL.
Rabbit Anti-CADPS2 Polyclonal Antibody – Cat# MBS150554

Immunohistochemistry (IHC) of anti-CADPS2 antibody

Immunohistochemistry of CAPS2 in human brain with CAPS2 antibody at 5 μg/mL.
Rabbit Anti-CADPS2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150554

Immunofluorescence (IF) of anti-CADPS2 antibody

Immunofluorescence of CAPS2 in Human Brain tissue with CAPS2 antibody at 20 μg/mL.
Rabbit Anti-CADPS2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150554

Other Notes

Small volumes of anti-CADPS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CADPS2. It may not necessarily be applicable to this product.

NCBI GI #
148839294
NCBI GeneID
93664
NCBI Accession #
NP_060424
UniProt Primary Accession #
Q86UW7
UniProt Secondary Accession #
Q658Q2; Q7Z5T7; Q8IZW9; Q8N7M4; Q9H6P4; Q9HCI1; Q9NWK8; A4D0X3; B7ZM56
UniProt Related Accession #
Q86UW7
GenBank Nucleotide #
NM_017954.10
NCBI Official Full Name
calcium-dependent secretion activator 2 isoform a
NCBI Official Synonym Full Names
Ca++-dependent secretion activator 2
NCBI Official Symbol
CADPS2
UniProt Protein Name
Calcium-dependent secretion activator 2
UniProt Synonym Protein Names
Calcium-dependent activator protein for secretion 2; CAPS-2
Protein Family
Calcium-dependent secretion activator
UniProt Gene Name
CADPS2
UniProt Synonym Gene Names
CAPS2; KIAA1591; CAPS-2
UniProt Entry Name
CAPS2_HUMAN
NCBI Protein Information
calcium-dependent secretion activator 2; CAPS-2; Ca2+-dependent activator protein for secretion 2; calcium-dependent activator protein for secretion 2

NCBI Summary for CADPS2

This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
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UniProt Comments for CADPS2

CADPS2: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 7q31.3

Cellular Component: presynaptic membrane; postsynaptic membrane; cytoplasmic vesicle membrane; cell junction

Molecular Function: metal ion binding; lipid binding

Biological Process: protein transport; cellular response to starvation; synaptic vesicle priming; positive regulation of exocytosis
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Research Articles on CADPS2

1. Mutation screening of 187 patients with autism spectrum disorders and 36 with intellectual disability identified a missense change of maternal origin disrupting CADPS2/D2DR interaction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CADPS2 antibody

 Disease Name  Pubmed Publications
 Autistic Disorder Antibodies  >8 publications with CADPS2 and Autistic Disorder
 Nervous System Diseases Antibodies  >5 publications with CADPS2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >5 publications with CADPS2 and Disease Models, Animal
 Congenital Abnormalities Antibodies  >1 publications with CADPS2 and Congenital Abnormalities
 Inflammation Antibodies  >1 publications with CADPS2 and Inflammation

Organs/Tissues associated with anti-CADPS2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with CADPS2 and Brain
 Nerve Antibodies  >10 publications with CADPS2 and Nerve
 Thyroid Antibodies  >1 publications with CADPS2 and Thyroid
 Thymus Antibodies  >1 publications with CADPS2 and Thymus
 Salivary Gland Antibodies  >1 publications with CADPS2 and Salivary Gland
 Spleen Antibodies  >1 publications with CADPS2 and Spleen
 Kidney Antibodies  >1 publications with CADPS2 and Kidney
 Stomach Antibodies  >1 publications with CADPS2 and Stomach
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