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NLRP11 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150563

NALP11 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP11 has a C-terminal… More details

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Product Overview

Online Datasheet in PDF
Product Name
NALP11 (NLRP11), Polyclonal Antibody
Full Product Name
NALP11 Antibody
Product Gene Name
anti-NLRP11 antibody
Product Synonym Names
NALP11; NOD17; PAN10; NALP11; PYPAF6; PYPAF7; CLR19.6; NOD17; NACHT; LRR and PYD domains-containing protein 11; Nucleotide-binding oligomerization domain protein 17; NLR family, pyrin domain containing 11
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
NALP11 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
NALP11 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
NALP11 peptide (MBS152322) is used for blocking the activity of NALP11 antibody (MBS150563)
Molecular Weight
105,915 Da
OMIM
609664
3D Structure
ModBase 3D Structure for P59045
Conjugate
Unconjugated
Immunogen
NALP11 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human NALP11.
Buffer
NALP11 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-NLRP11 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-NLRP11 antibody
NALP11 antibody can be used for detection of NALP11 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-NLRP11 antibody

Western blot analysis of NALP11 in HeLa cell lysate with NALP11 antibody at 1 μg/mL.
Rabbit Anti-NLRP11 Polyclonal Antibody – Cat# MBS150563

Immunocytochemistry (IHC) of anti-NLRP11 antibody

Immunocytochemistry of NALP11 in HeLa cells with NALP11 antibody at 2.5 μg/mL.
Rabbit Anti-NLRP11 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS150563

Immunofluorescence (IF) of anti-NLRP11 antibody

Immunofluorescence of NALP11 in HeLa cells with NALP11 antibody at 20 μg/mL.
Rabbit Anti-NLRP11 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150563

Other Notes

Small volumes of anti-NLRP11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NLRP11 purchase

MBS150563 is an antibody targeting NLRP11. Also known as NALP11 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NLRP11. It may not necessarily be applicable to this product.

NCBI GI #
194018484
NCBI GeneID
204801
NCBI Accession #
NP_659444
UniProt Primary Accession #
P59045
UniProt Secondary Accession #
Q2TV85; Q2TV86; Q53ZZ0; Q8NBF5; C9JSF5
UniProt Related Accession #
P59045
GenBank Nucleotide #
NM_145007.3
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 11 isoform 1
NCBI Official Synonym Full Names
NLR family, pyrin domain containing 11
NCBI Official Symbol
NLRP11
NCBI Official Synonym Symbols
NOD17; PAN10; NALP11; PYPAF6; PYPAF7; CLR19.6
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 11
UniProt Synonym Protein Names
Nucleotide-binding oligomerization domain protein 17; PAAD-and NACHT domain-containing protein 10; PYRIN-containing APAF1-like protein 6
Protein Family
NACHT, LRR and PYD domains-containing protein
UniProt Gene Name
NLRP11
UniProt Synonym Gene Names
NALP11; NOD17; PAN10; PYPAF6
UniProt Entry Name
NAL11_HUMAN
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 11; PYRIN-containing APAF1-like protein 6; PAAD- and NACHT-containing protein 10B; PAAD-and NACHT domain-containing protein 10; NACHT, leucine rich repeat and PYD containing 11; nucleotide-binding oligomerization domain protein 17; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11

NCBI Summary for NLRP11

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
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UniProt Comments for NLRP11

NLRP11: Involved in inflammation (Potential). Belongs to the NLRP family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.43

Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen; ATP binding
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Research Articles on NLRP11

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NLRP11 antibody

 Reference Product  PubMed Publications
 FAM175A antibody  >1 publications with NLRP11 and FAM175A

Diseases associated with anti-NLRP11 antibody

 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >1 publications with NLRP11 and Chromosome Aberrations
 Immune System Diseases Antibodies  >1 publications with NLRP11 and Immune System Diseases
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