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IKBKAP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150596

IKAP Antibody: IKAP was initially identified as a scaffold protein of the IκB kinase complex that could bind to IKKα, IKKβ, NF-κB, and the NF-κB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that… More details

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Product Overview

Online Datasheet in PDF
Product Name
IKAP (IKBKAP), Polyclonal Antibody
Full Product Name
IKAP Antibody
Product Gene Name
anti-IKBKAP antibody
Product Synonym Names
IKAP; FD; DYS; ELP1; IKAP; IKI3; TOT1; Elongator complex protein 1; IkappaB kinase complex-associated protein; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
IKAP Antibody is affinity chromatography purified via peptide column.
Preparation and Storage
IKAP antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
IKAP peptide (MBS152267) is used for blocking the activity of IKAP antibody (MBS150596)
Molecular Weight
150,254 Da
OMIM
phenotype 603722
3D Structure
ModBase 3D Structure for O95163
Conjugate
Unconjugated
Immunogen
IKAP antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human IKAP.
Buffer
IKAP Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-IKBKAP antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-IKBKAP antibody
IKAP antibody can be used for detection of IKAP by Western blot at 0.5 to 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 1 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-IKBKAP antibody

Western blot analysis of IKAP in A-20 cell lysate with IKAP antibody at in (A) 0.5, and (B) 1 μg/mL.
Rabbit Anti-IKBKAP Polyclonal Antibody – Cat# MBS150596

Immunocytochemistry (IHC) of anti-IKBKAP antibody

Immunocytochemistry of IKAP in A-20 cells with IKAP antibody at 1 μg/mL.
Rabbit Anti-IKBKAP Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS150596

Immunofluorescence (IF) of anti-IKBKAP antibody

Immunofluorescence of IKAP in A20 cells with IKAP antibody at 20 μg/mL.
Rabbit Anti-IKBKAP Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150596

Other Notes

Small volumes of anti-IKBKAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IKBKAP purchase

MBS150596 is an antibody targeting IKBKAP. Also known as IKAP Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IKBKAP. It may not necessarily be applicable to this product.

NCBI GI #
3757822
NCBI GeneID
8518
NCBI Accession #
AAC64258
UniProt Primary Accession #
O95163
UniProt Secondary Accession #
Q5JSV2; Q9H327; Q9UG87
UniProt Related Accession #
O95163
NCBI Official Full Name
IkappaB kinase complex associated protein
NCBI Official Synonym Full Names
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
NCBI Official Symbol
IKBKAP
NCBI Official Synonym Symbols
FD; DYS; ELP1; IKAP; IKI3; TOT1
UniProt Protein Name
Elongator complex protein 1
UniProt Synonym Protein Names
IkappaB kinase complex-associated protein; IKK complex-associated protein; p150
UniProt Gene Name
IKBKAP
UniProt Synonym Gene Names
ELP1; IKAP; ELP1; IKK complex-associated protein
UniProt Entry Name
ELP1_HUMAN
NCBI Protein Information
elongator complex protein 1; p150; IKK complex-associated protein; ikappaB kinase complex-associated protein; elongator acetyltransferase complex subunit 1

NCBI Summary for IKBKAP

The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. [provided by RefSeq, Jul 2008]
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UniProt Comments for IKBKAP

IKBKAP: May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3. Belongs to the ELP1/IKA1 family.

Protein type: Protein kinase, regulatory subunit; Transcription regulation

Chromosomal Location of Human Ortholog: 9q31

Cellular Component: transcription elongation factor complex; Elongator holoenzyme complex; cytoplasm; nucleolus; histone acetyltransferase complex

Molecular Function: protein binding; signal transducer activity; phosphorylase kinase regulator activity

Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; RNA elongation from RNA polymerase II promoter; immune response; protein complex assembly; signal transduction; regulation of protein kinase activity; protein amino acid phosphorylation; positive regulation of cell migration

Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iii
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Research Articles on IKBKAP

1. IKBKAP mRNA levels decreased during a familial dysautonomia crisis and returned to baseline after recovery. The cause-and-effect relationship is unclear.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IKBKAP antibody

 Reference Product  PubMed Publications
 ELP3 antibody  >3 publications with IKBKAP and ELP3
 ELP2 antibody  >1 publications with IKBKAP and ELP2

Pathways associated with anti-IKBKAP antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with anti-IKBKAP antibody

 Disease Name  Pubmed Publications
 Dysautonomia, Familial Antibodies  >72 publications with IKBKAP and Dysautonomia, Familial
 Nervous System Diseases Antibodies  >66 publications with IKBKAP and Nervous System Diseases
 Congenital Abnormalities Antibodies  >62 publications with IKBKAP and Congenital Abnormalities
 Death Antibodies  >11 publications with IKBKAP and Death
 Necrosis Antibodies  >9 publications with IKBKAP and Necrosis
 Cardiovascular Diseases Antibodies  >7 publications with IKBKAP and Cardiovascular Diseases
 Inflammation Antibodies  >6 publications with IKBKAP and Inflammation
 Pain Antibodies  >5 publications with IKBKAP and Pain
 Nerve Degeneration Antibodies  >2 publications with IKBKAP and Nerve Degeneration
 Heart Diseases Antibodies  >2 publications with IKBKAP and Heart Diseases

Organs/Tissues associated with anti-IKBKAP antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with IKBKAP and Blood
 Brain Antibodies  >15 publications with IKBKAP and Brain
 Muscle Antibodies  >5 publications with IKBKAP and Muscle
 Embryonic Tissue Antibodies  >5 publications with IKBKAP and Embryonic Tissue
 Heart Antibodies  >4 publications with IKBKAP and Heart
 Kidney Antibodies  >3 publications with IKBKAP and Kidney
 Liver Antibodies  >2 publications with IKBKAP and Liver
 Skin Antibodies  >2 publications with IKBKAP and Skin
 Mouth Antibodies  >2 publications with IKBKAP and Mouth
 Lung Antibodies  >2 publications with IKBKAP and Lung
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