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KCNK12 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150598

KCNK12 Antibody: KCNK13 and KCNK12 (also known as THIK1 and 2) are the first two members of a novel two pore-forming P domains K+ channels subfamily. The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
KCNK12, Polyclonal Antibody
Full Product Name
KCNK12 Antibody
Product Gene Name
Product Synonym Names
KCNK12; THIK2; THIK-2; K2p12.1; Potassium channel subfamily K member 12; Tandem pore domain halothane-inhibited potassium channel 2; potassium channel, subfamily K, member 12
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
KCNK12 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
KCNK12 antibody is predicted to not cross-react with other KCNK protein family members.
Preparation and Storage
KCNK12 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
KCNK12 peptide (MBS152541) is used for blocking the activity of KCNK12 antibody (MBS150598)
Molecular Weight
46,889 Da
OMIM
607366
3D Structure
ModBase 3D Structure for Q9HB15
Conjugate
Unconjugated
Immunogen
KCNK12 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human KCNK12.
Buffer
KCNK12 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-KCNK12 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-KCNK12 antibody
KCNK12 antibody can be used for detection of KCNK12 by Western blot at 0.5 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-KCNK12 antibody

Western blot analysis of KCNK12 in rat brain tissue lysate with KCNK12 antibody at 0.5 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-KCNK12 Polyclonal Antibody – Cat# MBS150598

Immunohistochemistry (IHC) of anti-KCNK12 antibody

Immunohistochemistry of KCNK12 in mouse brain tissue with KCNK12 antibody at 5 μg/mL.
Rabbit Anti-KCNK12 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150598

Immunofluorescence (IF) of anti-KCNK12 antibody

Immunofluorescence of KCNK12 in mouse brain tissue with KCNK12 antibody at 20 μg/mL.
Rabbit Anti-KCNK12 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150598

Other Notes

Small volumes of anti-KCNK12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNK12 purchase

MBS150598 is an antibody targeting KCNK12. Also known as KCNK12 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNK12. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
potassium channel subfamily K member 12
NCBI Official Synonym Full Names
potassium channel, two pore domain subfamily K, member 12
NCBI Official Symbol
KCNK12
NCBI Official Synonym Symbols
THIK2; THIK-2; K2p12.1
UniProt Protein Name
Potassium channel subfamily K member 12
UniProt Synonym Protein Names
Tandem pore domain halothane-inhibited potassium channel 2; THIK-2
UniProt Gene Name
KCNK12
UniProt Synonym Gene Names
THIK-2
UniProt Entry Name
KCNKC_HUMAN
NCBI Protein Information
potassium channel subfamily K member 12; potassium channel, subfamily K, member 12; tandem pore domain potassium channel THIK-2; tandem pore domain halothane-inhibited potassium channel 2

NCBI Summary for KCNK12

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

UniProt Comments for KCNK12

KCNK12: Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p16.3

Cellular Component: integral to membrane

Molecular Function: potassium channel activity; voltage-gated ion channel activity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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