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IL17A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150637

IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-17 (IL17A), Polyclonal Antibody
Full Product Name
IL-17 Antibody
Product Gene Name
Product Synonym Names
IL-17; IL17; CTLA8; IL-17; IL-17A; IL17; Interleukin-17A; Cytotoxic T-lymphocyte-associated antigen 8; interleukin 17A
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
IL-17 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
IL-17 antibody can be stored at 4 degrees C for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
IL-17 peptide (MBS152361) is used for blocking the activity of IL-17 antibody (MBS150637)
Molecular Weight
17,504 Da
OMIM
603149
3D Structure
ModBase 3D Structure for Q16552
Conjugate
Unconjugated
Immunogen
IL-17 antibody was raised against a 19 amino acid synthetic peptide from near the center of human IL-17A.
Buffer
IL-17 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-IL17A antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-IL17A antibody
IL-17 antibody can be used for the detection of IL-17 by Western blot at 1 - 2 mug/ml

Western Blot (WB) of anti-IL17A antibody

Western blot analysis of 1 ng of recombinant human IL-17 with IL-17 antibody at 1 μg/ml.
Rabbit Anti-IL17A Polyclonal Antibody – Cat# MBS150637

Immunohistochemistry (IHC) of anti-IL17A antibody

Immunohistochemistry of IL-17 in human tonsil tissue with IL-17 antibody at 5 μg/ml.
Rabbit Anti-IL17A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150637

Immunofluorescence (IF) of anti-IL17A antibody

Immunofluorescence of IL-17 in human tonsil tissue with IL-17 antibody at 20 μg/ml.

Green: IL-17 Antibody (4887)
Blue: DAPI staining
Rabbit Anti-IL17A Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150637

Immunohistochemistry (IHC) of anti-IL17A antibody

Immunohistochemistry of IL-17 in mouse colon tissue with IL-17 antibody at 2 μg/ml.
Rabbit Anti-IL17A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150637

Immunofluorescence (IF) of anti-IL17A antibody

Immunofluorescence of IL-17 in A-20 cells with IL-17 antibody at 5 μg/ml.

Green: IL-17 Antibody (4887)
Blue: DAPI staining
Rabbit Anti-IL17A Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150637

Immunofluorescence (IF) of anti-IL17A antibody

Immunofluorescence of IL-17 in mouse thymus tissue with IL-17 Antibody at 20 μg/mL.
Rabbit Anti-IL17A Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150637

Other Notes

Small volumes of anti-IL17A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL17A purchase

MBS150637 is an antibody targeting IL17A. Also known as IL-17 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL17A. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-17A
NCBI Official Synonym Full Names
interleukin 17A
NCBI Official Symbol
IL17A
NCBI Official Synonym Symbols
IL17; CTLA8; IL-17; IL-17A
UniProt Protein Name
Interleukin-17A
UniProt Synonym Protein Names
Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
Protein Family
UniProt Gene Name
IL17A
UniProt Synonym Gene Names
CTLA8; IL17; IL-17; IL-17A; CTLA-8
UniProt Entry Name
IL17_HUMAN
NCBI Protein Information
interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

NCBI Summary for IL17A

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL17A

IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: extracellular space; external side of plasma membrane

Molecular Function: cytokine activity

Biological Process: cell death; cell-cell signaling; positive regulation of osteoclast differentiation; apoptosis; positive regulation of interleukin-23 production; protein amino acid glycosylation; positive regulation of transcription from RNA polymerase II promoter; immune response; inflammatory response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-IL17A antibody

 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >106 publications with IL17A and Mixed
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