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TREX2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150649

TREX2 Antibody: TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome,… More details

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Product Overview

Online Datasheet in PDF
Product Name
TREX2, Polyclonal Antibody
Full Product Name
TREX2 Antibody
Product Gene Name
Product Synonym Names
TREX2; Three prime repair exonuclease 2; three prime repair exonuclease 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
TREX2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
This TREX2 antibody will not cross-react with the related protein TREX1.
Preparation and Storage
Antibody can be stored at 4 degree C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
TREX2 peptide (MBS152991) is used for blocking the activity of TREX2 antibody (MBS150649)
Molecular Weight
25,922 Da
OMIM
300370
3D Structure
ModBase 3D Structure for Q9BQ50
Conjugate
Unconjugated
Immunogen
TREX2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TREX2.
Buffer
TREX2 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-TREX2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-TREX2 antibody
TREX2 antibody can be used for detection of TREX2 by Western blot at 2.5 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-TREX2 antibody

Western blot analysis of TREX2 in rat liver tissue lysate with TREX2 antibody at 2.5 μg/mL.
Rabbit Anti-TREX2 Polyclonal Antibody – Cat# MBS150649

Immunohistochemistry (IHC) of anti-TREX2 antibody

Immunohistochemistry of TREX2 in human liver tissue with TREX2 antibody at 2.5 μg/mL.
Rabbit Anti-TREX2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150649

Immunofluorescence (IF) of anti-TREX2 antibody

Immunofluorescence of TREX2 in Human Liver cells with TREX2 antibody at 20 μg/mL.
Rabbit Anti-TREX2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150649

Other Notes

Small volumes of anti-TREX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TREX2 purchase

MBS150649 is an antibody targeting TREX2. Also known as TREX2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TREX2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Three prime repair exonuclease 2
NCBI Official Synonym Full Names
three prime repair exonuclease 2
NCBI Official Symbol
TREX2
UniProt Protein Name
Three prime repair exonuclease 2
UniProt Synonym Protein Names
3'-5' exonuclease TREX2
UniProt Gene Name
TREX2
UniProt Entry Name
TREX2_HUMAN
NCBI Protein Information
three prime repair exonuclease 2; 3'-5' exonuclease TREX2 long form

NCBI Summary for TREX2

This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]

UniProt Comments for TREX2

TREX2: Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair. Belongs to the exonuclease superfamily. TREX family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Deoxyribonuclease; DNA repair, damage; EC 3.1.11.2

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: nucleus

Molecular Function: protein homodimerization activity; nucleic acid binding; 3'-5'-exodeoxyribonuclease activity; exodeoxyribonuclease III activity; magnesium ion binding

Biological Process: DNA repair; DNA catabolic process, exonucleolytic; DNA metabolic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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