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TYW3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150652

TYW3 Antibody: TYW3 is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TYW3, Polyclonal Antibody
Full Product Name
TYW3 Antibody
Product Gene Name
Product Synonym Names
TYW3; C1orf171; C1orf171; tRNA wybutosine-synthesizing protein 3 homolog; tRNA-yW-synthesizing protein 3; tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid; TYW3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration
1 mg/mL (lot specific)
Specificity
TYW3 antibody is predicted to not cross-react with other TYW protein family members. At least two isoforms of TYW3 are known to exist; this antibody will detect both isoforms.
Preparation and Storage
TYW3 antibody can be stored at 4 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
TYW3 peptide (MBS153117) is used for blocking the activity of TYW3 antibody (MBS150652)
OMIM
611245
3D Structure
ModBase 3D Structure for Q6IPR3
Conjugate
Unconjugated
Immunogen
TYW3 antibody was raised against a 17 amino acid synthetic peptide near the center of human TYW3.
Then immunogen is located within amino acids 160-210 of TYW3.
Homology
Predicted species reactivity based on immunogen sequence: Bovine (94%), Pig (94%)
Positive Control
1) Cat No. MBS151686 A549 Cell Lysate.
Applications Tested/Suitable for anti-TYW3 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-TYW3 antibody
TYW3 antibody can be used for detection of TYW3 by Western blot at 1 ug/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Western Blot (WB) of anti-TYW3 antibody

TYW3 Antibody
Rabbit Anti-TYW3 Polyclonal Antibody – Cat# MBS150652

Other Notes

Small volumes of anti-TYW3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TYW3 purchase

MBS150652 is an antibody targeting TYW3. Also known as TYW3 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TYW3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tRNA wybutosine-synthesizing protein 3 homolog isoform 1
NCBI Official Synonym Full Names
tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
NCBI Official Symbol
TYW3
NCBI Official Synonym Symbols
C1orf171
UniProt Protein Name
tRNA wybutosine-synthesizing protein 3 homolog
UniProt Synonym Protein Names
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase
UniProt Gene Name
TYW3
UniProt Synonym Gene Names
C1orf171; tRNA-yW-synthesizing protein 3
UniProt Entry Name
TYW3_HUMAN
NCBI Protein Information
tRNA wybutosine-synthesizing protein 3 homolog; tRNA-yW-synthesizing protein 3; tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase

NCBI Summary for TYW3

Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]
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UniProt Comments for TYW3

TYW3: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Belongs to the TYW3 family.

Protein type: Methyltransferase; EC 2.1.1.282

Chromosomal Location of Human Ortholog: 1p31.1

Molecular Function: methyltransferase activity

Biological Process: methylation; tRNA processing
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TYW3 antibody

 Reference Product  PubMed Publications
 TYW1 antibody  >3 publications with TYW3 and TYW1

Organs/Tissues associated with anti-TYW3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with TYW3 and Blood
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