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HAAO Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150662

HAAO Antibody: HAAO (3-Hydroxyanthranilate 3, 4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is… More details

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Product Overview

Online Datasheet in PDF
Product Name
HAAO, Polyclonal Antibody
Full Product Name
HAAO Antibody
Product Gene Name
anti-HAAO antibody
Product Synonym Names
HAAO; HAO; 3-HAO; 3-hydroxyanthranilate 3; 4-dioxygenase; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilate 3,4-dioxygenase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
HAAO Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
HAAO antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
HAAO peptide (MBS152992) is used for blocking the activity of HAAO antibody (MBS150662)
Molecular Weight
17,275 Da
OMIM
604521
3D Structure
ModBase 3D Structure for P46952
Conjugate
Unconjugated
Immunogen
HAAO antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human HAAO.
Buffer
HAAO Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-HAAO antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-HAAO antibody
HAAO antibody can be used for detection of HAAO by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-HAAO antibody

Western blot analysis of HAAO in Mouse liver tissue lysate with HAAO antibody at 1 μg/mL.
Rabbit Anti-HAAO Polyclonal Antibody – Cat# MBS150662

Immunohistochemistry (IHC) of anti-HAAO antibody

Immunohistochemistry of HAAO in human liver tissue with HAAO antibody at 2.5 μg/mL.
Rabbit Anti-HAAO Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150662

Immunofluorescence (IF) of anti-HAAO antibody

Immunofluorescence of HAAO in Human Liver cells with HAAO antibody at 20 μg/mL.
Rabbit Anti-HAAO Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150662

Other Notes

Small volumes of anti-HAAO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HAAO purchase

MBS150662 is an antibody targeting HAAO. Also known as HAAO Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HAAO. It may not necessarily be applicable to this product.

NCBI GI #
188497625
NCBI GeneID
23498
NCBI Accession #
NP_036337
UniProt Primary Accession #
P46952
UniProt Secondary Accession #
Q53QZ7; Q8N6N9; A6NE56; B4DIN2
UniProt Related Accession #
P46952
GenBank Nucleotide #
NM_012205.2
NCBI Official Full Name
3-hydroxyanthranilate 3,4-dioxygenase
NCBI Official Synonym Full Names
3-hydroxyanthranilate 3,4-dioxygenase
NCBI Official Symbol
HAAO
NCBI Official Synonym Symbols
HAO; 3-HAO
UniProt Protein Name
3-hydroxyanthranilate 3,4-dioxygenase
UniProt Synonym Protein Names
3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase
UniProt Gene Name
HAAO
UniProt Entry Name
3HAO_HUMAN
NCBI Protein Information
3-hydroxyanthranilate 3,4-dioxygenase; HAD; HAAO; 3-HAO; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase

NCBI Summary for HAAO

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq, Jul 2008]
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UniProt Comments for HAAO

HAAO: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Belongs to the 3-HAO family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.6; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: mitochondrial membrane; cytosol

Molecular Function: electron carrier activity; ferrous iron binding; oxygen binding; 3-hydroxyanthranilate 3,4-dioxygenase activity

Biological Process: anthranilate metabolic process; response to cadmium ion; response to zinc ion; quinolinate biosynthetic process; tryptophan catabolic process
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Research Articles on HAAO

1. Methylation status of CIDEA, HAAO and RXFP3 had significant association with microsatellite instability in endometrial tumors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HAAO antibody

 Reference Product  PubMed Publications
 KMO antibody  >1 publications with HAAO and KMO

Pathways associated with anti-HAAO antibody

 Products by Pathway  Pathway Diagram
 L-kynurenine Degradation Pathway antibodies  L-kynurenine Degradation Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 NAD Biosynthesis II (from Tryptophan) Pathway antibodies  NAD Biosynthesis II (from Tryptophan) Pathway Diagram
 NAD De Novo Biosynthesis Pathway antibodies  NAD De Novo Biosynthesis Pathway Diagram
 Tryptophan Catabolism Pathway antibodies  Tryptophan Catabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram

Diseases associated with anti-HAAO antibody

 Disease Name  Pubmed Publications
 Prostatic Diseases Antibodies  >1 publications with HAAO and Prostatic Diseases
 Hyperplasia Antibodies  >1 publications with HAAO and Hyperplasia

Organs/Tissues associated with anti-HAAO antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with HAAO and Blood
 Brain Antibodies  >1 publications with HAAO and Brain
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