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RASD2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150695

TEM2 Antibody: Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily… More details

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Product Overview

Online Datasheet in PDF
Product Name
TEM2 (RASD2), Polyclonal Antibody
Full Product Name
TEM2 Antibody
Product Gene Name
anti-RASD2 antibody
Product Synonym Names
TEM2; Rhes; TEM2; MGC:4834; GTP-binding protein Rhes; Ras homolog enriched in striatum; RASD family, member 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
TEM2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
TEM2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
TEM2 peptide (MBS153017) is used for blocking the activity of TEM2 antibody (MBS150695)
Molecular Weight
30,366 Da
OMIM
612842
3D Structure
ModBase 3D Structure for Q96D21
Conjugate
Unconjugated
Immunogen
TEM2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human TEM2.
Buffer
TEM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-RASD2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-RASD2 antibody
TEM2 antibody can be used for detection of TEM2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-RASD2 antibody

Western blot analysis of TEM2 in human colon tissue lysate with TEM2 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-RASD2 Polyclonal Antibody – Cat# MBS150695

Immunohistochemistry (IHC) of anti-RASD2 antibody

Immunohistochemistry of TEM2 in human colon tissue with TEM2 antibody at 2.5 μg/mL.
Rabbit Anti-RASD2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150695

Immunofluorescence (IF) of anti-RASD2 antibody

Immunofluorescence of TEM2 in Human Colon cells with TEM2 antibody at 20 μg/mL.
Rabbit Anti-RASD2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150695

Other Notes

Small volumes of anti-RASD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RASD2 purchase

MBS150695 is an antibody targeting RASD2. Also known as TEM2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RASD2. It may not necessarily be applicable to this product.

NCBI GI #
21362868
NCBI GeneID
23551
NCBI Accession #
Q96D21.1
UniProt Primary Accession #
Q96D21
UniProt Secondary Accession #
O95520; Q5THY8
UniProt Related Accession #
Q96D21
NCBI Official Full Name
GTP-binding protein Rhes
NCBI Official Synonym Full Names
RASD family, member 2
NCBI Official Symbol
RASD2
NCBI Official Synonym Symbols
Rhes; TEM2; MGC:4834
UniProt Protein Name
GTP-binding protein Rhes
UniProt Synonym Protein Names
Ras homolog enriched in striatum; Tumor endothelial marker 2
Protein Family
GTP-binding protein
UniProt Gene Name
RASD2
UniProt Synonym Gene Names
TEM2
UniProt Entry Name
RHES_HUMAN
NCBI Protein Information
GTP-binding protein Rhes; tumor endothelial marker 2; Ras homolog enriched in striatum

NCBI Summary for RASD2

This gene encodes a Ras-related protein that enriched in striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades. [provided by RefSeq, Jul 2008]
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UniProt Comments for RASD2

RASD2: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. Belongs to the small GTPase superfamily. RasD family.

Protein type: G protein, monomeric, RasD; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: plasma membrane

Molecular Function: GTPase activity; GTP binding; ubiquitin conjugating enzyme binding; G-protein beta-subunit binding

Biological Process: positive regulation of protein sumoylation; synaptic transmission, dopaminergic; positive regulation of protein kinase B signaling cascade; metabolic process; small GTPase mediated signal transduction; locomotory behavior; negative regulation of protein ubiquitination
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Research Articles on RASD2

1. The findings of this study suggested that Rhes may play a crucial role in striatal iron homeostasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RASD2 antibody

 Reference Product  PubMed Publications
 ADRB2 antibody  >1 publications with RASD2 and ADRB2
 TSHR antibody  >1 publications with RASD2 and TSHR
 FSHR antibody  >1 publications with RASD2 and FSHR

Diseases associated with anti-RASD2 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >7 publications with RASD2 and Disease Models, Animal
 Learning Disorders Antibodies  >2 publications with RASD2 and Learning Disorders
 Seizures Antibodies  >1 publications with RASD2 and Seizures
 Poisoning Antibodies  >1 publications with RASD2 and Poisoning
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with RASD2 and Drug-Related Side Effects and Adverse Reactions
 Memory Disorders Antibodies  >1 publications with RASD2 and Memory Disorders

Organs/Tissues associated with anti-RASD2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >24 publications with RASD2 and Brain
 Liver Antibodies  >1 publications with RASD2 and Liver
 Intestine Antibodies  >1 publications with RASD2 and Intestine
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