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BCAS3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150707

BCAS3 Antibody: The Breast carcinoma amplified sequence (BCAS3) gene is localized to 17q23, a region that is often amplified in breast cancers. Copy number gains at this region have also been reported in other tumors such as brain, lung, liver, testis and… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
BCAS3, Polyclonal Antibody
Full Product Name
BCAS3 Antibody
Product Gene Name
anti-BCAS3 antibody
Product Synonym Names
BCAS3; MAAB; GAOB1; Breast carcinoma-amplified sequence 3; breast carcinoma amplified sequence 3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
BCAS3 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
BCAS3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
BCAS3 peptide (MBS152298) is used for blocking the activity of BCAS3 antibody (MBS150707)
Molecular Weight
74,240 Da
OMIM
607470
3D Structure
ModBase 3D Structure for Q9H6U6
Conjugate
Unconjugated
Immunogen
BCAS3 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human BCAS3.
Buffer
BCAS3 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-BCAS3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-BCAS3 antibody
BCAS3 antibody can be used for detection of BCAS3 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-BCAS3 antibody

Western blot analysis of BCAS3 in rat brain tissue lysate with BCAS3 antibody at (A) 0.5 and (B) 1 μg/mL.
Rabbit Anti-BCAS3 Polyclonal Antibody – Cat# MBS150707

Immunohistochemistry (IHC) of anti-BCAS3 antibody

Immunohistochemistry of BCAS3 in human breast carcinoma with BCAS3 antibody at 5 μg/mL.
Rabbit Anti-BCAS3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150707

Immunofluorescence (IF) of anti-BCAS3 antibody

Immunofluorescence of BCAS3 in human breast carcinoma tissue with BCAS3 antibody at 20 μg/mL.
Rabbit Anti-BCAS3 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150707

Other Notes

Small volumes of anti-BCAS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCAS3 purchase

MBS150707 is an antibody targeting BCAS3. Also known as BCAS3 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BCAS3. It may not necessarily be applicable to this product.

NCBI GI #
119571800
NCBI GeneID
54828
NCBI Accession #
EAW51415
UniProt Primary Accession #
Q9H6U6
UniProt Secondary Accession #
Q17RM0; Q6KF21; Q8IXI6; Q8NDR8; Q8TDL9; Q8TDM1; Q8WY55; Q9BVF0; Q9H957; Q9H9Y9; Q9NXP4
UniProt Related Accession #
Q9H6U6
NCBI Official Full Name
breast carcinoma amplified sequence 3, isoform CRA_f
NCBI Official Synonym Full Names
breast carcinoma amplified sequence 3
NCBI Official Symbol
BCAS3
NCBI Official Synonym Symbols
MAAB; GAOB1
UniProt Protein Name
Breast carcinoma-amplified sequence 3
UniProt Synonym Protein Names
GAOB1
Protein Family
Breast carcinoma-amplified sequence
UniProt Gene Name
BCAS3
UniProt Entry Name
BCAS3_HUMAN
NCBI Protein Information
breast carcinoma-amplified sequence 3; protein Maab1; BCAS4/BCAS3 fusion; metastasis associated antigen of breast cancer; breast carcinoma amplified sequence 4/3 fusion protein

UniProt Comments for BCAS3

BCAS3: A chromosomal aberration involving BCAS3 has been found in some breast carcinoma cell lines. Translocation t(17;20)(q23;q13) with BCAS4. Belongs to the WD repeat BCAS3 family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q23

Cellular Component: intermediate filament cytoskeleton; cytoplasmic microtubule; leading edge; cytoplasm; nucleus

Molecular Function: histone acetyltransferase binding; protein binding; histone binding; beta-tubulin binding; chromatin binding; transcription factor binding; nuclear hormone receptor binding

Biological Process: positive regulation of catalytic activity; positive regulation of filopodium formation; vesicle-mediated transport; response to starvation; microtubule organizing center organization and biogenesis; transcription, DNA-dependent; negative regulation of focal adhesion formation; lumen formation; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; Golgi organization and biogenesis
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Research Articles on BCAS3

1. Real-time PCR validated that up-regulation of sulphiredoxin 1 homolog (SRXN1), hemeoxygenase 1 (HMOX1), and breast carcinoma amplified sequence 3 (BCAS3) were consistently modulated.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-BCAS3 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >7 publications with BCAS3 and Breast Neoplasms
 Carcinoma Antibodies  >5 publications with BCAS3 and Carcinoma
 Neoplasm Metastasis Antibodies  >3 publications with BCAS3 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >3 publications with BCAS3 and Kidney Diseases
 Lung Diseases Antibodies  >1 publications with BCAS3 and Lung Diseases
 Adenocarcinoma Antibodies  >1 publications with BCAS3 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >1 publications with BCAS3 and Cardiovascular Diseases
 Body Weight Changes Antibodies  >1 publications with BCAS3 and Body Weight Changes
 Congenital Abnormalities Antibodies  >1 publications with BCAS3 and Congenital Abnormalities
 Microsatellite Instability Antibodies  >1 publications with BCAS3 and Microsatellite Instability

Organs/Tissues associated with anti-BCAS3 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with BCAS3 and Kidney
 Heart Antibodies  >2 publications with BCAS3 and Heart
 Brain Antibodies  >2 publications with BCAS3 and Brain
 Liver Antibodies  >1 publications with BCAS3 and Liver
 Embryonic Tissue Antibodies  >1 publications with BCAS3 and Embryonic Tissue
 Lung Antibodies  >1 publications with BCAS3 and Lung
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