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CCDC22 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150741

CCDC22 Antibody: CCDC22 is a recently identified coiled-coil domain-containing protein that has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. In rat, CCDC22 has been observed to… More details

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Product Overview

Online Datasheet in PDF
Product Name
CCDC22, Polyclonal Antibody
Full Product Name
CCDC22 Antibody
Product Gene Name
anti-CCDC22 antibody
Product Synonym Names
CCDC22; JM1; CXorf37; JM1; Coiled-coil domain-containing protein 22; coiled-coil domain containing 22
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
CCDC22 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least three isoforms of CCDC22 are known to exist; this antibody will detect the two largest isoforms.
Preparation and Storage
CCDC22 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
CCDC22 peptide (MBS152517) is used for blocking the activity of CCDC22 antibody (MBS150741)
Molecular Weight
70,756 Da
OMIM
300859
3D Structure
ModBase 3D Structure for O60826
Conjugate
Unconjugated
Immunogen
CCDC22 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CCDC22.
Buffer
CCDC22 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-CCDC22 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-CCDC22 antibody
CCDC22 antibody can be used for detection of CCDC22 by Western blot at 1 - 2 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-CCDC22 antibody

Western blot analysis of CCDC22 in 293 cell lysate with CCDC22 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-CCDC22 Polyclonal Antibody – Cat# MBS150741

Immunofluorescence (IF) of anti-CCDC22 antibody

Immunofluorescence of CCDC22 in human brain tissue with CCDC22 antibody at 20 μg/mL.
Rabbit Anti-CCDC22 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150741

Other Notes

Small volumes of anti-CCDC22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCDC22 purchase

MBS150741 is an antibody targeting CCDC22. Also known as CCDC22 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCDC22. It may not necessarily be applicable to this product.

NCBI GI #
7661844
NCBI GeneID
28952
NCBI Accession #
NP_054727
UniProt Primary Accession #
O60826
UniProt Secondary Accession #
A8K7G1
UniProt Related Accession #
O60826
GenBank Nucleotide #
NM_014008.4
NCBI Official Full Name
coiled-coil domain-containing protein 22
NCBI Official Synonym Full Names
coiled-coil domain containing 22
NCBI Official Symbol
CCDC22
NCBI Official Synonym Symbols
JM1; CXorf37
UniProt Protein Name
Coiled-coil domain-containing protein 22
Protein Family
Coiled-coil domain-containing protein
UniProt Gene Name
CCDC22
UniProt Synonym Gene Names
CXorf37
UniProt Entry Name
CCD22_HUMAN
NCBI Protein Information
coiled-coil domain-containing protein 22

NCBI Summary for CCDC22

This gene encodes a protein containing a coiled-coil domain. The encoded protein functions in the regulation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) by interacting with COMMD (copper metabolism Murr1 domain-containing) proteins. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability. [provided by RefSeq, Aug 2013]
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UniProt Comments for CCDC22

CCDC22: May be involved in X-linked syndromic mental retardation (PubMed:21826058). CCDC22 expression has been found to be down-regulated in a family with a phenotype consistent with X- linked syndromic mental retardation, and carrying variant Ala-17. In addition to intellectual disability, affected individuals have cardiac and skeletal abnormalities. Belongs to the CCDC22 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: endosome

Molecular Function: protein binding

Biological Process: Golgi to plasma membrane transport; protein transport; cellular copper ion homeostasis; positive regulation of I-kappaB kinase/NF-kappaB cascade; cytoplasmic sequestering of NF-kappaB; negative regulation of I-kappaB kinase/NF-kappaB cascade
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Research Articles on CCDC22

1. CCDC22 participates in NF-kappaB activation and its deficiency leads to decreased IkappaB turnover

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CCDC22 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >2 publications with CCDC22 and Congenital Abnormalities
 Neurobehavioral Manifestations Antibodies  >2 publications with CCDC22 and Neurobehavioral Manifestations
 Abnormalities, Multiple Antibodies  >1 publications with CCDC22 and Abnormalities, Multiple
 Craniofacial Abnormalities Antibodies  >1 publications with CCDC22 and Craniofacial Abnormalities
 Heart Defects, Congenital Antibodies  >1 publications with CCDC22 and Heart Defects, Congenital
 Inflammation Antibodies  >1 publications with CCDC22 and Inflammation

Organs/Tissues associated with anti-CCDC22 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with CCDC22 and Lung
 Blood Antibodies  >1 publications with CCDC22 and Blood
 Brain Antibodies  >1 publications with CCDC22 and Brain
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