• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TNFRSF10C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150747

DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DcR1 (TNFRSF10C), Polyclonal Antibody
Full Product Name
DcR1 Antibody
Product Gene Name
Product Synonym Names
DcR1; LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR; LIT; UNQ321/PRO366; Tumor necrosis factor receptor superfamily member 10C; Decoy TRAIL receptor without death domain; DcR1; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
DcR1 Antibody is DEAE purified.
Preparation and Storage
Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
DcR1 peptide (MBS152727) is used for blocking the activity of DcR1 antibody (MBS150747)
Molecular Weight
65 kDa
OMIM
603613
3D Structure
ModBase 3D Structure for O14798
Conjugate
Unconjugated
Immunogen
DcR1 antibody was raised against a peptide corresponding to amino acids in the extracellular domain of human DcR1 precursor.
Buffer
DcR1 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-TNFRSF10C antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-TNFRSF10C antibody
DcR1 antibody can be used for detection of DcR1 by Western blot at 1 mug/mL. An approximate 65 kDa band can be detected. Antibody can also be used for immunoflourescence starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-TNFRSF10C antibody

Western blot analysis of DcR1 in HeLa cell (A), mouse (B) and rat (C) liver tissue lysates with DcR1 antibody at 1 μg/mL.
Rabbit Anti-TNFRSF10C Polyclonal Antibody – Cat# MBS150747

Immunofluorescence (IF) of anti-TNFRSF10C antibody

Immunofluorescence of DcR1 in rat liver tissue with DcR1 antibody at 10 μg/mL.
Rabbit Anti-TNFRSF10C Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150747

Immunofluorescence (IF) of anti-TNFRSF10C antibody

Immunofluorescence of DcR1 in Rat Liver cells with DcR1 antibody at 20 μg/mL.
Rabbit Anti-TNFRSF10C Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150747

Other Notes

Small volumes of anti-TNFRSF10C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF10C purchase

MBS150747 is an antibody targeting TNFRSF10C. Also known as DcR1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF10C. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens decoy receptor 1 (DcR1) mRNA, complete cds
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
NCBI Official Symbol
TNFRSF10C
NCBI Official Synonym Symbols
LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10C
UniProt Synonym Protein Names
Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular domain; CD_antigen: CD263
UniProt Gene Name
TNFRSF10C
UniProt Synonym Gene Names
DCR1; LIT; TRAILR3; TRID; DcR1; TRAIL receptor 3; TRAIL-R3
UniProt Entry Name
TR10C_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10C; decoy receptor 1; cytotoxic TRAIL receptor-3; lymphocyte inhibitor of TRAIL; decoy TRAIL receptor without death domain; antagonist decoy receptor for TRAIL/Apo-2L; TNF-related apoptosis-inducing ligand receptor 3

NCBI Summary for TNFRSF10C

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for TNFRSF10C

TRAIL-R3: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 8p22-p21

Cellular Component: integral to plasma membrane

Molecular Function: transmembrane receptor activity; TRAIL binding

Biological Process: apoptosis; signal transduction
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000