TRIM30 Antibody – Rabbit Polyclonal

TRIM30A: Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses

Cellular Component: cytoplasm; intracellular; nucleus

Molecular Function: DNA binding; zinc ion binding; metal ion binding

Biological Process: protein autoubiquitination; transcription, DNA-dependent; positive regulation of virion penetration into host cell; regulation of transcription, DNA-dependent; positive regulation of protein catabolic process; negative regulation of interleukin-6 production; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production