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CNKSR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150788

AIF Antibody: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
AIF (CNKSR1), Polyclonal Antibody
Full Product Name
AIF Antibody
Product Gene Name
anti-CNKSR1 antibody
Product Synonym Names
AIF; CNK; KSR; CNK1; Connector enhancer of kinase suppressor of ras 1; CNK homolog protein 1; Connector enhancer of KSR 1; connector enhancer of kinase suppressor of Ras 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
AIF Antibody is Ion exchange chromatography purified.
Preparation and Storage
AIF antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
AIF peptide (MBS152679) is used for blocking the activity of AIF antibody (MBS150788)
Molecular Weight
67 kDa
OMIM
603272
3D Structure
ModBase 3D Structure for O95381
Conjugate
Unconjugated
Immunogen
AIF antibody was raised against a 15 amino acid peptide near the center of human AIF.
Buffer
AIF Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-CNKSR1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CNKSR1 antibody
AIF antibody can be used for detection of AIF by Western blot at 1 mug/mL. A 67 kDa band should be detected. Antibody can also be used for immunohistochemistry starting at 10 mug/mL.

Western Blot (WB) of anti-CNKSR1 antibody

Western blot analysis of AIF in K562 cell lysate (A), rat heart (B), and mouse heart (C) tissue lysates with AIF antibody (IN) at 1 μg/mL.
Rabbit Anti-CNKSR1 Polyclonal Antibody – Cat# MBS150788

Immunohistochemistry (IHC) of anti-CNKSR1 antibody

Immunohistochemistry of AIF in human retina tissue with AIF antibody at 10 μg/mL.
Rabbit Anti-CNKSR1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150788

Other Notes

Small volumes of anti-CNKSR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNKSR1 purchase

MBS150788 is an antibody targeting CNKSR1. Also known as AIF Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CNKSR1. It may not necessarily be applicable to this product.

NCBI GI #
50400606
NCBI GeneID
10256
NCBI Accession #
Q969H4.1
UniProt Primary Accession #
O95381
UniProt Secondary Accession #
O95381; B1AMW9
UniProt Related Accession #
Q969H4
NCBI Official Full Name
Connector enhancer of kinase suppressor of ras 1
NCBI Official Synonym Full Names
connector enhancer of kinase suppressor of Ras 1
NCBI Official Symbol
CNKSR1
NCBI Official Synonym Symbols
CNK; CNK1
UniProt Protein Name
Connector enhancer of kinase suppressor of ras 1
UniProt Synonym Protein Names
CNK homolog protein 1; CNK1; hCNK1; Connector enhancer of KSR-like
Protein Family
Connector enhancer of kinase suppressor of ras
UniProt Gene Name
CNKSR1
UniProt Synonym Gene Names
CNK1; Connector enhancer of KSR 1; CNK1; hCNK1
UniProt Entry Name
CNKR1_HUMAN
NCBI Protein Information
connector enhancer of kinase suppressor of ras 1; CNK homolog protein 1; connector enhancer of KSR 1

NCBI Summary for CNKSR1

This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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UniProt Comments for CNKSR1

CNK1: a RAF-binding multidomain protein required for RAS signaling. Contains several protein-protein interaction domains. Its PH domain interacts with Rho in a GTP-dependent manner. Associates with Rhophilin and RalGDS, Rho and Ras effector molecules. Two alternatively spliced isoforms have been described.

Protein type: G protein regulator, misc.; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: plasma membrane; cell cortex; intercellular junction

Molecular Function: protein binding, bridging

Biological Process: Ras protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; Rho protein signal transduction
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Research Articles on CNKSR1

1. CNK1 mediates ephrinB1 signaling that promotes cell migration through RhoA and JNK activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CNKSR1 antibody

 Reference Product  PubMed Publications
 KSR1 antibody  >3 publications with CNKSR1 and KSR1
 RASSF1 antibody  >1 publications with CNKSR1 and RASSF1
 RHOA antibody  >1 publications with CNKSR1 and RHOA

Diseases associated with anti-CNKSR1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with CNKSR1 and Breast Neoplasms
 Recurrence Antibodies  >1 publications with CNKSR1 and Recurrence
 Disease Models, Animal Antibodies  >1 publications with CNKSR1 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with CNKSR1 and Inflammation

Organs/Tissues associated with anti-CNKSR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with CNKSR1 and Heart
 Embryonic Tissue Antibodies  >1 publications with CNKSR1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with CNKSR1 and Kidney
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