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BAP31 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150797

BAP31 Antibody: Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family. These two proteins are highly homologous and can form homo- and heterodimers.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
BAP31 (BCAP31), Polyclonal Antibody
Full Product Name
BAP31 Antibody
Product Gene Name
anti-BCAP31 antibody
Product Synonym Names
BAP31; CDM; DDCH; BAP31; 6C6-AG; DXS1357E; B-cell receptor-associated protein 31; 6C6-AG tumor-associated antigen; BCR-associated protein 31; B-cell receptor-associated protein 31
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
BAP31 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
BAP31 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
BAP31 peptide (MBS151802) is used for blocking the activity of BAP31 antibody (MBS150797)
Molecular Weight
34,752 Da
OMIM
gene 300475
3D Structure
ModBase 3D Structure for P51572
Conjugate
Unconjugated
Immunogen
BAP31 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human BAP31.
Buffer
BAP31 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-BCAP31 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-BCAP31 antibody
BAP31 antibody can be used for the detection of BAP31 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2 mug/mL.

Western Blot (WB) of anti-BCAP31 antibody

Western blot analysis of BAP31 in Ramos cell lysate with BAP31 antibody at (A) 0.5, (B) 1 and (C) 2μg/mL.
Rabbit Anti-BAP31 Polyclonal Antibody – Cat# MBS150797

Immunohistochemistry (IHC) of anti-BCAP31 antibody

Immunohistochemistry of BAP31 in rat lung tissue with BAP31 antibody at 2 μg/mL.
Rabbit Anti-BAP31 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150797

Other Notes

Small volumes of anti-BCAP31 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCAP31 purchase

MBS150797 is an antibody targeting BCAP31. Also known as BAP31 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BCAP31. It may not necessarily be applicable to this product.

NCBI GI #
32171186
NCBI GeneID
10134
NCBI Accession #
NP_005736
UniProt Primary Accession #
P51572
UniProt Secondary Accession #
Q13836; Q96CF0; B3KQ79; D3DWV5
UniProt Related Accession #
P51572
GenBank Nucleotide #
NM_005745.7
NCBI Official Full Name
B-cell receptor-associated protein 31 isoform b
NCBI Official Synonym Full Names
B-cell receptor-associated protein 31
NCBI Official Symbol
BCAP31
NCBI Official Synonym Symbols
CDM; DDCH; BAP31; 6C6-AG; DXS1357E
UniProt Protein Name
B-cell receptor-associated protein 31
UniProt Synonym Protein Names
6C6-AG tumor-associated antigen; Protein CDM; p28
Protein Family
B-cell receptor-associated protein
UniProt Gene Name
BCAP31
UniProt Synonym Gene Names
BAP31; DXS1357E; BCR-associated protein 31; Bap31
UniProt Entry Name
BAP31_HUMAN
NCBI Protein Information
B-cell receptor-associated protein 31; p28 Bap31; BCR-associated protein Bap31; 6C6-AG tumor-associated antigen

NCBI Summary for BCAP31

This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]
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UniProt Comments for BCAP31

BCAP31 iso2: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis. Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB. Ubiquitous. Belongs to the BCAP29/BCAP31 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; membrane; clathrin-coated vesicle; integral to plasma membrane; endoplasmic reticulum; lipid particle; cytosol

Molecular Function: protein binding; MHC class I protein binding; protein complex binding

Biological Process: intracellular protein transport; ER to Golgi vesicle-mediated transport; antigen processing and presentation of peptide antigen via MHC class I; elevation of cytosolic calcium ion concentration; apoptosis; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of caspase activity; spermatogenesis; cell structure disassembly during apoptosis; elevation of mitochondrial calcium ion concentration

Disease: Deafness, Dystonia, And Cerebral Hypomyelination
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Research Articles on BCAP31

1. Hypomethylation in BCAP31 is associated with breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BCAP31 antibody

 Reference Product  PubMed Publications
 CASP8 antibody  >23 publications with BCAP31 and CASP8
 ABCD1 antibody  >4 publications with BCAP31 and ABCD1
 CFTR antibody  >1 publications with BCAP31 and CFTR

Pathways associated with anti-BCAP31 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Programmed Cell Death Pathway antibodies  Programmed Cell Death Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-BCAP31 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >5 publications with BCAP31 and Necrosis
 Nervous System Diseases Antibodies  >4 publications with BCAP31 and Nervous System Diseases
 Neurobehavioral Manifestations Antibodies  >2 publications with BCAP31 and Neurobehavioral Manifestations
 Cardiovascular Diseases Antibodies  >2 publications with BCAP31 and Cardiovascular Diseases
 Fibrosis Antibodies  >1 publications with BCAP31 and Fibrosis
 Anemia Antibodies  >1 publications with BCAP31 and Anemia
 Lung Neoplasms Antibodies  >1 publications with BCAP31 and Lung Neoplasms
 Lung Diseases Antibodies  >1 publications with BCAP31 and Lung Diseases
 Inflammation Antibodies  >1 publications with BCAP31 and Inflammation

Organs/Tissues associated with anti-BCAP31 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with BCAP31 and Blood
 Liver Antibodies  >5 publications with BCAP31 and Liver
 Brain Antibodies  >5 publications with BCAP31 and Brain
 Testis Antibodies  >4 publications with BCAP31 and Testis
 Muscle Antibodies  >4 publications with BCAP31 and Muscle
 Kidney Antibodies  >3 publications with BCAP31 and Kidney
 Thymus Antibodies  >3 publications with BCAP31 and Thymus
 Bone Marrow Antibodies  >2 publications with BCAP31 and Bone Marrow
 Spleen Antibodies  >2 publications with BCAP31 and Spleen
 Bone Antibodies  >2 publications with BCAP31 and Bone
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