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APC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150831

APC2 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
APC2, Polyclonal Antibody
Full Product Name
APC2 Antibody
Product Gene Name
anti-APC2 antibody
Product Synonym Names
APC2; APCL; APCL; Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APC-like; adenomatosis polyposis coli 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
APC2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
APC2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
APC2 peptide (MBS152821) is used for blocking the activity of APC2 antibody (MBS150831)
Molecular Weight
243,821 Da
OMIM
612034
3D Structure
ModBase 3D Structure for O95996
Conjugate
Unconjugated
Immunogen
APC2 antibody was raised against an 18 amino acid synthetic peptide near the center of human APC2.
Buffer
APC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-APC2 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-APC2 antibody
APC2 antibody can be used for detection of APC2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-APC2 antibody

Western blot analysis of APC2 in HeLa cell lysate with APC2 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-APC2 Polyclonal Antibody – Cat# MBS150831

Immunocytochemistry (IHC) of anti-APC2 antibody

Immunocytochemistry of APC2 in HeLa cells with APC2 antibody at 5 μg/mL.
Rabbit Anti-APC2 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS150831

Immunofluorescence (IF) of anti-APC2 antibody

Immunofluorescence of APC2 in HeLa cells with APC2 antibody at 20 μg/mL.
Rabbit Anti-APC2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150831

Other Notes

Small volumes of anti-APC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APC2 purchase

MBS150831 is an antibody targeting APC2. Also known as APC2 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for APC2. It may not necessarily be applicable to this product.

NCBI GI #
3894265
NCBI GeneID
10297
NCBI Accession #
BAA34611
UniProt Primary Accession #
O95996
UniProt Secondary Accession #
Q05BW4; Q9UBZ1; Q9UEM8; Q9UQJ8; Q9UQJ9; Q9Y632
UniProt Related Accession #
O95996
NCBI Official Full Name
APCL protein
NCBI Official Synonym Full Names
adenomatosis polyposis coli 2
NCBI Official Symbol
APC2
NCBI Official Synonym Symbols
APCL
UniProt Protein Name
Adenomatous polyposis coli protein 2
UniProt Synonym Protein Names
Adenomatous polyposis coli protein-like; APC-like
Protein Family
Acetophenone carboxylase
UniProt Gene Name
APC2
UniProt Synonym Gene Names
APCL; APC-like
UniProt Entry Name
APC2_HUMAN
NCBI Protein Information
adenomatous polyposis coli protein 2; adenomatous polyposis coli like

UniProt Comments for APC2

APCL: Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling. Belongs to the adenomatous polyposis coli (APC) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: microtubule cytoskeleton; Golgi membrane; Golgi apparatus; perinuclear region of cytoplasm; cytoplasmic microtubule; cytoplasm; actin filament; catenin complex

Molecular Function: protein binding; microtubule binding; beta-catenin binding

Biological Process: Wnt receptor signaling pathway
Show more

Research Articles on APC2

1. APCL uses the 15 amino acid repeats region of APC to target beta-catenin for degradation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-APC2 antibody

 Reference Product  PubMed Publications
 CTNNB1 antibody  >26 publications with APC2 and CTNNB1
 CDH1 antibody  >10 publications with APC2 and CDH1
 CDC27 antibody  >8 publications with APC2 and CDC27
 AXIN1 antibody  >1 publications with APC2 and AXIN1
 MAPRE3 antibody  >1 publications with APC2 and MAPRE3
 AXIN2 antibody  >1 publications with APC2 and AXIN2

Pathways associated with anti-APC2 antibody

 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Endometrial Cancer Pathway antibodies  Endometrial Cancer Pathway Diagram
 Endometrial Cancer Pathway antibodies  Endometrial Cancer Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram

Diseases associated with anti-APC2 antibody

 Disease Name  Pubmed Publications
 Colorectal Neoplasms Antibodies  >16 publications with APC2 and Colorectal Neoplasms
 Lung Neoplasms Antibodies  >4 publications with APC2 and Lung Neoplasms
 Lung Diseases Antibodies  >4 publications with APC2 and Lung Diseases
 Inflammation Antibodies  >1 publications with APC2 and Inflammation
 Infertility, Male Antibodies  >1 publications with APC2 and Infertility, Male
 Learning Disorders Antibodies  >1 publications with APC2 and Learning Disorders
 Memory Disorders Antibodies  >1 publications with APC2 and Memory Disorders
 Cognition Disorders Antibodies  >1 publications with APC2 and Cognition Disorders
 Hyperplasia Antibodies  >1 publications with APC2 and Hyperplasia
 Kidney Diseases Antibodies  >1 publications with APC2 and Kidney Diseases

Organs/Tissues associated with anti-APC2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with APC2 and Brain
 Embryonic Tissue Antibodies  >8 publications with APC2 and Embryonic Tissue
 Lung Antibodies  >5 publications with APC2 and Lung
 Testis Antibodies  >4 publications with APC2 and Testis
 Nerve Antibodies  >4 publications with APC2 and Nerve
 Eye Antibodies  >4 publications with APC2 and Eye
 Liver Antibodies  >2 publications with APC2 and Liver
 Intestine Antibodies  >1 publications with APC2 and Intestine
 Kidney Antibodies  >1 publications with APC2 and Kidney
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