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ESX1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150856

ESX1 Antibody: Homeobox proteins are transcription factors that contain a helix-turn-helix DNA binding domain termed the homeodomain. ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis and contains two functional domains: the… More details

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Product Overview

Online Datasheet in PDF
Product Name
ESX1, Polyclonal Antibody
Full Product Name
ESX1 Antibody
Product Gene Name
anti-ESX1 antibody
Product Synonym Names
ESX1; ESX1L; ESXR1; ESX1L; ESX1R; Homeobox protein ESX1; Extraembryonic; spermatogenesis; homeobox 1; ESX homeobox 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
ESX1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
ESX1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
ESX1 peptide (MBS151800) is used for blocking the activity of ESX1 antibody (MBS150856)
Molecular Weight
44,297 Da
OMIM
300154
3D Structure
ModBase 3D Structure for Q8N693
Conjugate
Unconjugated
Immunogen
ESX1 antibody was raised against a 19 amino acid synthetic peptide near the center of human ESX1.
Buffer
ESX1 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-ESX1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ESX1 antibody
ESX1 antibody can be used for detection of ESX1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-ESX1 antibody

Western blot analysis of ESX1 in human testis tissue lysate with ESX1 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-ESX1 Polyclonal Antibody – Cat# MBS150856

Immunohistochemistry (IHC) of anti-ESX1 antibody

Immunohistochemistry of ESX1 in human testis tissue with ESX1 antibody at 2.5 μg/mL.
Rabbit Anti-ESX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150856

Immunofluorescence (IF) of anti-ESX1 antibody

Immunofluorescence of ESX1 in human testis tissue with ESX1 antibody at 20 μg/mL.
Rabbit Anti-ESX1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150856

Other Notes

Small volumes of anti-ESX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ESX1 purchase

MBS150856 is an antibody targeting ESX1. Also known as ESX1 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ESX1. It may not necessarily be applicable to this product.

NCBI GI #
116241356
NCBI GeneID
80712
NCBI Accession #
Q8N693.3
UniProt Primary Accession #
Q8N693
UniProt Secondary Accession #
Q7Z6K7; B0QYU3
UniProt Related Accession #
Q8N693
NCBI Official Full Name
Homeobox protein ESX1
NCBI Official Synonym Full Names
ESX homeobox 1
NCBI Official Symbol
ESX1
NCBI Official Synonym Symbols
ESX1L; ESXR1
UniProt Protein Name
Homeobox protein ESX1
UniProt Synonym Protein Names
Extraembryonic, spermatogenesis, homeobox 1Cleaved into the following 2 chains:Homeobox protein ESX1-N; Homeobox protein ESX1-C
Protein Family
Homeobox protein
UniProt Gene Name
ESX1
UniProt Synonym Gene Names
ESX1L; ESX1R
UniProt Entry Name
ESX1_HUMAN
NCBI Protein Information
homeobox protein ESX1; ESX1-related protein; extraembryonic, spermatogenesis, homeobox 1 homolog

NCBI Summary for ESX1

This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010]
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UniProt Comments for ESX1

ESX1L: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: Xq22.1

Cellular Component: cytoplasm; nucleus

Molecular Function: sequence-specific DNA binding

Biological Process: transcription, DNA-dependent; regulation of cell cycle; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
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Research Articles on ESX1

1. ESX1 emerges as a potentially reliable molecular marker of residual spermatogenesis in azoospermic men

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ESX1 antibody

 Products by Pathway  Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram

Diseases associated with anti-ESX1 antibody

 Disease Name  Pubmed Publications
 Fetal Diseases Antibodies  >5 publications with ESX1 and Fetal Diseases
 Fetal Growth Retardation Antibodies  >4 publications with ESX1 and Fetal Growth Retardation
 Growth Disorders Antibodies  >4 publications with ESX1 and Growth Disorders
 Necrosis Antibodies  >4 publications with ESX1 and Necrosis
 Infertility, Male Antibodies  >1 publications with ESX1 and Infertility, Male
 Cleft Palate Antibodies  >1 publications with ESX1 and Cleft Palate
 Congenital Abnormalities Antibodies  >1 publications with ESX1 and Congenital Abnormalities
 Fetal Death Antibodies  >1 publications with ESX1 and Fetal Death
 Embryo Loss Antibodies  >1 publications with ESX1 and Embryo Loss

Organs/Tissues associated with anti-ESX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >11 publications with ESX1 and Testis
 Brain Antibodies  >1 publications with ESX1 and Brain
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