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ZFYVE26 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150880

SPG15 Antibody: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.  Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SPG15 (ZFYVE26), Polyclonal Antibody
Full Product Name
SPG15 Antibody
Product Gene Name
anti-ZFYVE26 antibody
Product Synonym Names
SPG15; SPG15; FYVE-CENT; KIAA0321; Zinc finger FYVE domain-containing protein 26; FYVE domain-containing centrosomal protein; zinc finger, FYVE domain containing 26
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
SPG15 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
SPG15 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
SPG15 peptide (MBS152259) is used for blocking the activity of SPG15 antibody (MBS150880)
Molecular Weight
77,970 Da
OMIM
phenotype 612012
3D Structure
ModBase 3D Structure for Q68DK2
Conjugate
Unconjugated
Immunogen
SPG15 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human SPG15.
Buffer
SPG15 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-ZFYVE26 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-ZFYVE26 antibody
SPG15 antibody can be used for detection of SPG15 by Western blot at 0.5 - 1 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-ZFYVE26 antibody

Western blot analysis of SPG15 in K562 cell lysate with SPG15 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-ZFYVE26 Polyclonal Antibody – Cat# MBS150880

Immunofluorescence (IF) of anti-ZFYVE26 antibody

Immunofluorescence of SPG15 in Mouse Heart tissue with SPG15 antibody at 20 μg/mL.
Rabbit Anti-ZFYVE26 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150880

Other Notes

Small volumes of anti-ZFYVE26 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZFYVE26 purchase

MBS150880 is an antibody targeting ZFYVE26. Also known as SPG15 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ZFYVE26. It may not necessarily be applicable to this product.

NCBI GI #
119601358
NCBI GeneID
23503
NCBI Accession #
EAW80952
UniProt Primary Accession #
Q68DK2
UniProt Secondary Accession #
O15035; Q68DT9; Q6AW90; Q6ZR50; Q7Z3A4; Q7Z3I1; Q8N4W7; B1B5Y3; B4E2U3
UniProt Related Accession #
Q68DK2
NCBI Official Full Name
zinc finger, FYVE domain containing 26, isoform CRA_a
NCBI Official Synonym Full Names
zinc finger, FYVE domain containing 26
NCBI Official Symbol
ZFYVE26
NCBI Official Synonym Symbols
SPG15; FYVE-CENT
UniProt Protein Name
Zinc finger FYVE domain-containing protein 26
UniProt Synonym Protein Names
FYVE domain-containing centrosomal protein; FYVE-CENT; Spastizin
Protein Family
Zinc finger FYVE domain-containing protein
UniProt Gene Name
ZFYVE26
UniProt Synonym Gene Names
KIAA0321; FYVE-CENT
UniProt Entry Name
ZFY26_HUMAN
NCBI Protein Information
zinc finger FYVE domain-containing protein 26; spastizin; FYVE domain-containing centrosomal protein

NCBI Summary for ZFYVE26

This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
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UniProt Comments for ZFYVE26

ZFYVE26: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A. Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: centrosome; lysosomal membrane; midbody

Molecular Function: protein binding; metal ion binding; phosphatidylinositol 3-phosphate binding

Biological Process: cytokinesis; double-strand break repair via homologous recombination

Disease: Spastic Paraplegia 15, Autosomal Recessive
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Research Articles on ZFYVE26

1. ZFYVE26 is a key determinant of autophagosome maturation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ZFYVE26 antibody

 Reference Product  PubMed Publications
 SPG11 antibody  >7 publications with ZFYVE26 and SPG11
 FA2H antibody  >2 publications with ZFYVE26 and FA2H
 SPG21 antibody  >2 publications with ZFYVE26 and SPG21
 GJC2 antibody  >1 publications with ZFYVE26 and GJC2
 PNPLA6 antibody  >1 publications with ZFYVE26 and PNPLA6
 KIAA0415 antibody  >1 publications with ZFYVE26 and KIAA0415

Diseases associated with anti-ZFYVE26 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >7 publications with ZFYVE26 and Congenital Abnormalities
 Breast Neoplasms Antibodies  >3 publications with ZFYVE26 and Breast Neoplasms
 Carcinoma Antibodies  >2 publications with ZFYVE26 and Carcinoma
 Spastic paraplegia 15, autosomal recessive Antibodies  >1 publications with ZFYVE26 and Spastic paraplegia 15, autosomal recessive

Organs/Tissues associated with anti-ZFYVE26 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with ZFYVE26 and Brain
 Muscle Antibodies  >2 publications with ZFYVE26 and Muscle
 Eye Antibodies  >1 publications with ZFYVE26 and Eye
 Skin Antibodies  >1 publications with ZFYVE26 and Skin
 Embryonic Tissue Antibodies  >1 publications with ZFYVE26 and Embryonic Tissue
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