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Maelstrom (MAEL) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150904

Maelstrom Antibody: The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatoid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a… More details

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Product Overview

Online Datasheet in PDF
Product Name
Maelstrom, Polyclonal Antibody
Full Product Name
Maelstrom Antibody
Product Gene Name
anti-MAEL antibody
Product Synonym Names
Maelstrom; CT128; SPATA35; Protein maelstrom homolog; maelstrom homolog (Drosophila)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Maelstrom Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
Maelstrom antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
Maelstrom peptide (MBS153104) is used for blocking the activity of Maelstrom antibody (MBS150904)
Molecular Weight
17,268 Da
OMIM
611368
3D Structure
ModBase 3D Structure for Q96JY0
Conjugate
Unconjugated
Immunogen
Maelstrom antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human Maelstrom.
Buffer
Maelstrom Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-MAEL antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-MAEL antibody
Maelstrom antibody can be used for detection of Maelstrom by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-MAEL antibody

Western blot analysis of Maelstrom in HeLa cell lysate with Maelstrom antibody at 1 μg/mL.
Rabbit Anti-MAEL Polyclonal Antibody – Cat# MBS150904

Immunocytochemistry (IHC) of anti-MAEL antibody

Immunocytochemistry of Maelstrom in HeLa cells with Maelstrom antibody at 5 μg/mL.
Rabbit Anti-MAEL Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS150904

Immunofluorescence (IF) of anti-MAEL antibody

Immunofluorescence of Maelstrom in HeLa cells with Maelstrom antibody at 20 μg/mL.
Rabbit Anti-MAEL Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150904

Other Notes

Small volumes of anti-MAEL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAEL purchase

MBS150904 is an antibody targeting MAEL. Also known as Maelstrom Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAEL. It may not necessarily be applicable to this product.

NCBI GI #
67866977
NCBI GeneID
84944
NCBI Accession #
AAY82463
UniProt Primary Accession #
Q96JY0
UniProt Secondary Accession #
Q49AP9; Q5VZP8; Q9UIW6; B4DY43; E9JVC3
UniProt Related Accession #
Q96JY0
NCBI Official Full Name
maelstrom
NCBI Official Synonym Full Names
maelstrom spermatogenic transposon silencer
NCBI Official Symbol
MAEL
NCBI Official Synonym Symbols
CT128; SPATA35
UniProt Protein Name
Protein maelstrom homolog
Protein Family
Protein maelstrom
UniProt Gene Name
MAEL
UniProt Entry Name
MAEL_HUMAN
NCBI Protein Information
protein maelstrom homolog; cancer/testis antigen 128; spermatogenesis associated 35

UniProt Comments for MAEL

MAEL: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage. Belongs to the maelstrom family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 1q24.1

Cellular Component: XY body; autosome; perinuclear region of cytoplasm; cytoplasm; nucleus; chromatin

Molecular Function: DNA binding

Biological Process: fertilization; DNA damage response, signal transduction resulting in induction of apoptosis; DNA methylation during gametogenesis; multicellular organismal development; synapsis; cell morphogenesis; gene expression; regulation of organ growth; RNA-mediated gene silencing; spermatogenesis; negative regulation of transcription from RNA polymerase II promoter; male meiosis; cell differentiation; negative regulation of apoptosis
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Research Articles on MAEL

1. Immunofluorescence analysis showed that MAEL co-localizes with the stress granule marker PABPC1 in stress granules during oxidative stress. MAEL may be involved in miRNA-mediated gene silencing in SGs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MAEL antibody

 Reference Product  PubMed Publications
 PIWIL2 antibody  >4 publications with MAEL and PIWIL2
 PIWIL1 antibody  >3 publications with MAEL and PIWIL1
 DDX4 antibody  >3 publications with MAEL and DDX4
 TDRD9 antibody  >2 publications with MAEL and TDRD9
 PIWIL4 antibody  >2 publications with MAEL and PIWIL4
 TDRD1 antibody  >2 publications with MAEL and TDRD1
 MOV10L1 antibody  >1 publications with MAEL and MOV10L1
 TDRD6 antibody  >1 publications with MAEL and TDRD6
 SIN3B antibody  >1 publications with MAEL and SIN3B

Pathways associated with anti-MAEL antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 PIWI-interacting RNA (piRNA) Biogenesis Pathway antibodies  PIWI-interacting RNA (piRNA) Biogenesis Pathway Diagram
 Regulatory RNA Pathways antibodies  Regulatory RNA Pathways Diagram

Diseases associated with anti-MAEL antibody

 Disease Name  Pubmed Publications
 Colorectal Neoplasms Antibodies  >4 publications with MAEL and Colorectal Neoplasms
 Intestinal Neoplasms Antibodies  >4 publications with MAEL and Intestinal Neoplasms
 Adenocarcinoma Antibodies  >3 publications with MAEL and Adenocarcinoma
 Carcinoma Antibodies  >2 publications with MAEL and Carcinoma
 Immune System Diseases Antibodies  >2 publications with MAEL and Immune System Diseases
 Immunologic Deficiency Syndromes Antibodies  >2 publications with MAEL and Immunologic Deficiency Syndromes
 Infertility, Male Antibodies  >1 publications with MAEL and Infertility, Male
 Necrosis Antibodies  >1 publications with MAEL and Necrosis
 Lung Neoplasms Antibodies  >1 publications with MAEL and Lung Neoplasms
 Breast Neoplasms Antibodies  >1 publications with MAEL and Breast Neoplasms

Organs/Tissues associated with anti-MAEL antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >9 publications with MAEL and Testis
 Heart Antibodies  >2 publications with MAEL and Heart
 Eye Antibodies  >1 publications with MAEL and Eye
 Liver Antibodies  >1 publications with MAEL and Liver
 Embryonic Tissue Antibodies  >1 publications with MAEL and Embryonic Tissue
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