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GPR124 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150910

TEM5 Antibody: Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TEM5 (GPR124), Polyclonal Antibody
Full Product Name
TEM5 Antibody
Product Gene Name
anti-GPR124 antibody
Product Synonym Names
TEM5; TEM5; KIAA1531; TEM5; G-protein coupled receptor 124; Tumor endothelial marker 5; G protein-coupled receptor 124
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Liquid
Purity/Purification
TEM5 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
TEM5 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
TEM5 peptide (MBS152177) is used for blocking the activity of TEM5 antibody (MBS150910)
Molecular Weight
19,530 Da
OMIM
606823
3D Structure
ModBase 3D Structure for Q96PE1
Conjugate
Unconjugated
Immunogen
TEM5 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human TEM5.
Buffer
TEM5 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-GPR124 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GPR124 antibody
TEM5 antibody can be used for detection of TEM5 by Western blot at 2 and 4 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.

Western Blot (WB) of anti-GPR124 antibody

Western blot analysis of TEM5 in human bladder tissue lysate with TEM5 antibody at (A) 2 and (B) 4 μg/mL.
Rabbit Anti-GPR124 Polyclonal Antibody – Cat# MBS150910

Immunohistochemistry (IHC) of anti-GPR124 antibody

Immunohistochemistry of TEM5 in human bladder tissue with TEM5 antibody at 5 μg/mL.
Rabbit Anti-GPR124 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS150910

Other Notes

Small volumes of anti-GPR124 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPR124 purchase

MBS150910 is an antibody targeting GPR124. Also known as TEM5 Antibody. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GPR124. It may not necessarily be applicable to this product.

NCBI GI #
221222450
NCBI GeneID
25960
NCBI Accession #
Q96PE1.2
UniProt Primary Accession #
Q96PE1
UniProt Secondary Accession #
Q8N3R1; Q8TEM3; Q96KB2; Q9P1Z7; Q9UFY4; A6H8W3; D3DSW4
UniProt Related Accession #
Q96PE1
NCBI Official Full Name
G-protein coupled receptor 124
NCBI Official Synonym Full Names
G protein-coupled receptor 124
NCBI Official Symbol
GPR124
NCBI Official Synonym Symbols
TEM5
UniProt Protein Name
G-protein coupled receptor 124
UniProt Synonym Protein Names
Tumor endothelial marker 5
UniProt Gene Name
GPR124
UniProt Synonym Gene Names
KIAA1531; TEM5
UniProt Entry Name
GP124_HUMAN
NCBI Protein Information
G-protein coupled receptor 124; tumor endothelial marker 5

UniProt Comments for GPR124

GPR124: Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 2; Receptor, GPCR

Chromosomal Location of Human Ortholog: 8p11.23

Cellular Component: cell surface; integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; central nervous system development; regulation of chemotaxis; endothelial cell migration; sprouting angiogenesis; regulation of angiogenesis
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Research Articles on GPR124

1. Observed an inverse correlation between the expression of miR-138-5p and GPR124 in lung adenocarcinoma specimens. Knockdown of GPR124 mimicked the effects of miR-138-5p on the sensitivity to gefitinib.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GPR124 antibody

 Reference Product  PubMed Publications
 GPR111 antibody  >1 publications with GPR124 and GPR111

Pathways associated with anti-GPR124 antibody

 Products by Pathway  Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram

Diseases associated with anti-GPR124 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with GPR124 and Disease Models, Animal
 Neural Tube Defects Antibodies  >1 publications with GPR124 and Neural Tube Defects
 Memory Disorders Antibodies  >1 publications with GPR124 and Memory Disorders
 Neoplasms, Experimental Antibodies  >1 publications with GPR124 and Neoplasms, Experimental
 Learning Disorders Antibodies  >1 publications with GPR124 and Learning Disorders
 Nervous System Malformations Antibodies  >1 publications with GPR124 and Nervous System Malformations

Organs/Tissues associated with anti-GPR124 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with GPR124 and Brain
 Embryonic Tissue Antibodies  >6 publications with GPR124 and Embryonic Tissue
 Lung Antibodies  >3 publications with GPR124 and Lung
 Nerve Antibodies  >2 publications with GPR124 and Nerve
 Muscle Antibodies  >1 publications with GPR124 and Muscle
 Heart Antibodies  >1 publications with GPR124 and Heart
 Spinal Cord Antibodies  >1 publications with GPR124 and Spinal Cord
 Eye Antibodies  >1 publications with GPR124 and Eye
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