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TNFRSF14 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS150920

TNFRSF14 Antibody: Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was… More details

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Product Overview

Online Datasheet in PDF
Product Name
TNFRSF14, Polyclonal Antibody
Full Product Name
TNFRSF14 Antibody
Product Gene Name
anti-TNFRSF14 antibody
Product Synonym Names
TNFRSF14; TR2; ATAR; HVEA; HVEM; CD270; LIGHTR; UNQ329/PRO509; Tumor necrosis factor receptor superfamily member 14; Herpes virus entry mediator A; Herpesvirus entry mediator A; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
TNFRSF14 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
TNFRSF14 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
TNFRSF14 peptide (MBS152871) is used for blocking the activity of TNFRSF14 antibody (MBS150920)
Molecular Weight
21,351 Da
OMIM
602746
3D Structure
ModBase 3D Structure for Q92956
Conjugate
Unconjugated
Immunogen
TNFRSF14 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human TNFRSF14.
Buffer
TNFRSF14 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-TNFRSF14 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-TNFRSF14 antibody
TNFRSF14 antibody can be used for the detection of TNFRSF14 by Western blot at 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-TNFRSF14 antibody

Western blot analysis of TNFRSF14 in Raji cell lysate with TNFRSF14 antibody at 2 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-TNFRSF14 Polyclonal Antibody – Cat# MBS150920

Immunocytochemistry (IHC) of anti-TNFRSF14 antibody

Immunocytochemistry of TNFRSF14 in Raji with TNFRSF14 antibody at 10 μg/mL.
Rabbit Anti-TNFRSF14 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS150920

Immunofluorescence (IF) of anti-TNFRSF14 antibody

Immunofluorescence of TNFRSF14 in Raji cells with TNFRSF14 antibody at 20 μg/mL.
Rabbit Anti-TNFRSF14 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS150920

Western Blot (WB) of anti-TNFRSF14 antibody

Western blot analysis of 5 ng of TNFRSF14 with TNFRSF14 antibody at 1 μg/mL.
Rabbit Anti-TNFRSF14 Polyclonal Antibody, Western Blot (WB) – Cat# MBS150920

Other Notes

Small volumes of anti-TNFRSF14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF14 purchase

MBS150920 is an antibody targeting TNFRSF14. Also known as TNFRSF14 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF14. It may not necessarily be applicable to this product.

NCBI GI #
13878821
NCBI GeneID
8764
NCBI Accession #
Q92956.3
UniProt Primary Accession #
Q92956
UniProt Secondary Accession #
Q6IB95; Q8N634; Q8WXR1; Q96J31; Q9UM65; B3KW30; B9DI89
UniProt Related Accession #
Q92956
NCBI Official Full Name
Tumor necrosis factor receptor superfamily member 14
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 14
NCBI Official Symbol
TNFRSF14
NCBI Official Synonym Symbols
TR2; ATAR; HVEA; HVEM; CD270; LIGHTR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 14
UniProt Synonym Protein Names
Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; Tumor necrosis factor receptor-like 2; TR2; CD_antigen: CD270
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF14
UniProt Synonym Gene Names
HVEA; HVEM; Herpesvirus entry mediator A; HveA; TR2
UniProt Entry Name
TNR14_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 14; CD40-like protein; herpes virus entry mediator A; tumor necrosis factor receptor-like gene2; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

NCBI Summary for TNFRSF14

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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UniProt Comments for TNFRSF14

TNFRSF14: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.

Protein type: Membrane protein, integral; Receptor, misc.; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p36.32

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: viral receptor activity; protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; entry of virus into host cell; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; T cell costimulation; positive regulation of cytokine secretion during immune response; negative regulation of alpha-beta T cell proliferation; immune response; defense response to Gram-negative bacterium
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Research Articles on TNFRSF14

1. Relative expression of HVEM and LTbetaR modulates canonical NF-kappaB and pro-apoptotic signals stimulated by LIGHT.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNFRSF14 antibody

 Reference Product  PubMed Publications
 BTLA antibody  >71 publications with TNFRSF14 and BTLA
 TNFSF14 antibody  >67 publications with TNFRSF14 and TNFSF14
 TRAF2 antibody  >5 publications with TNFRSF14 and TRAF2

Pathways associated with anti-TNFRSF14 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with anti-TNFRSF14 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >281 publications with TNFRSF14 and Necrosis
 Inflammation Antibodies  >39 publications with TNFRSF14 and Inflammation
 Arthritis, Rheumatoid Antibodies  >20 publications with TNFRSF14 and Arthritis, Rheumatoid
 Carcinoma Antibodies  >9 publications with TNFRSF14 and Carcinoma
 Nervous System Diseases Antibodies  >9 publications with TNFRSF14 and Nervous System Diseases
 Liver Diseases Antibodies  >8 publications with TNFRSF14 and Liver Diseases
 Neoplasms, Experimental Antibodies  >6 publications with TNFRSF14 and Neoplasms, Experimental
 Anemia Antibodies  >5 publications with TNFRSF14 and Anemia
 Carcinoma, Hepatocellular Antibodies  >2 publications with TNFRSF14 and Carcinoma, Hepatocellular
 Anemia, Hemolytic Antibodies  >2 publications with TNFRSF14 and Anemia, Hemolytic

Organs/Tissues associated with anti-TNFRSF14 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >145 publications with TNFRSF14 and Blood
 Bone Antibodies  >14 publications with TNFRSF14 and Bone
 Liver Antibodies  >11 publications with TNFRSF14 and Liver
 Intestine Antibodies  >11 publications with TNFRSF14 and Intestine
 Eye Antibodies  >11 publications with TNFRSF14 and Eye
 Spleen Antibodies  >10 publications with TNFRSF14 and Spleen
 Lymph Node Antibodies  >10 publications with TNFRSF14 and Lymph Node
 Lymph Antibodies  >9 publications with TNFRSF14 and Lymph
 Muscle Antibodies  >7 publications with TNFRSF14 and Muscle
 Ovary Antibodies  >7 publications with TNFRSF14 and Ovary
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