• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

HVCN1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151000

HVCN1 (hydrogen voltage-gated channel 1), a voltage gated proton channel protein that is highly expressed in immune tissues, mediates the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing. HVCN1… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HVCN1, Polyclonal Antibody
Full Product Name
HVCN1 Antibody
Product Gene Name
anti-HVCN1 antibody
Product Synonym Names
Hydrogen voltage-gated channel 1; HV1; VSOP; Voltage sensor domain-only protein; (CT) Hydrogen voltage-gated channel 1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, mouse, rat
Form/Format
Liquid. PBS containing 0.02% sodium azide.
Purity/Purification
Affinity chromatography purified via peptide column
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for three months and -20 degree C. Stable for up to one year.
Antibody/Peptide Pairs
HVCN1 peptide (MBS152216) is used for blocking the activity of HVCN1 antibody (MBS151000)
Molecular Weight
31,683 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (111086491..111127617, complement). Location: 12q24.11
OMIM
611227
3D Structure
ModBase 3D Structure for Q96D96
Immunogen
17 amino acid peptide near the carboxy terminus of human HVCN1.
Blocking Peptide
MBS152216 HVCN1 Peptide
Positive Control 1
MBS151674 Spleen Lysate
Applications Tested/Suitable for anti-HVCN1 antibody
ELISA, Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-HVCN1 antibody
HVCN1 antibody can be used for detection of HVCN1 by Western Blot at 0.5 - 1 ug/mL.

Western Blot (WB) of anti-HVCN1 antibody

Western blot analysis of HVCN1 in (A) human spleen and (B) mouse spleen tissue lysates with HVCN1 antibody at 1 μg/mL.
Rabbit Anti-HVCN1 Polyclonal Antibody – Cat# MBS151000

Immunohistochemistry (IHC) of anti-HVCN1 antibody

Immunohistochemistry of HVCN1 in rat spleen tissue with HVCN1 antibody at 5 μg/mL.
Rabbit Anti-HVCN1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151000

Immunofluorescence (IF) of anti-HVCN1 antibody

Immunofluorescence of HVCN1 in Rat Spleen cells with HVCN1 antibody at 20 μg/mL.
Rabbit Anti-HVCN1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151000

Product References and Citations for anti-HVCN1 antibody

* Ramsey IS, Moran MM, Chong JA, et al. A voltage gated proton-selective channel lacking the pore domain. Nature2006; 440:1213-6.
* Sasaki M, Takagi M, and Okamura Y. A voltage sensor-domain protein is a voltage-gated proton channel. Science2006; 312: 589-92.
* Morgan D, Capasso M, and Musset B. Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc. Natl. Acad. Sci. USA2009; 106:18022-7.
* Capasso M, Bhamrah MK, Henley T, et al. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nat. Immunol.2010;11:265-72.

Other Notes

Small volumes of anti-HVCN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HVCN1 purchase

MBS151000 is an antibody targeting HVCN1. Also known as HVCN1 Antibody. Reactive in Human, mouse, rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HVCN1. It may not necessarily be applicable to this product.

NCBI GI #
91992155
NCBI GeneID
84329
NCBI Accession #
NP_115745
UniProt Primary Accession #
Q96D96
UniProt Secondary Accession #
Q6UW11; Q96IS5; A8MQ37
UniProt Related Accession #
Q96D96
GenBank Nucleotide #
NM_032369.3
NCBI Official Full Name
voltage-gated hydrogen channel 1 isoform 1
NCBI Official Synonym Full Names
hydrogen voltage-gated channel 1
NCBI Official Symbol
HVCN1
NCBI Official Synonym Symbols
HV1; VSOP
UniProt Protein Name
Voltage-gated hydrogen channel 1
UniProt Synonym Protein Names
Hydrogen voltage-gated channel 1; HV1; Voltage sensor domain-only protein
Protein Family
Voltage-gated hydrogen channel
UniProt Gene Name
HVCN1
UniProt Synonym Gene Names
VSOP; HV1
UniProt Entry Name
HVCN1_HUMAN
NCBI Protein Information
voltage-gated hydrogen channel 1; voltage sensor domain-only protein

NCBI Summary for HVCN1

This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Show more

UniProt Comments for HVCN1

HVCN1: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. Belongs to the hydrogen channel family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: voltage-gated cation channel activity; voltage-gated proton channel activity

Biological Process: sperm-egg recognition; proton transport; response to zinc ion; single fertilization; multicellular organism reproduction; response to pH
Show more

Research Articles on HVCN1

1. Hv1-dependent reactive oxygen species production is responsible for a substantial fraction of brain damage at early time points after ischemic stroke.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-HVCN1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with HVCN1 and Inflammation
 Neoplasms Antibodies  >1 publications with HVCN1 and Neoplasms
 Asthma Antibodies  >1 publications with HVCN1 and Asthma
 Respiratory Tract Infections Antibodies  >1 publications with HVCN1 and Respiratory Tract Infections

Organs/Tissues associated with anti-HVCN1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with HVCN1 and Blood
 Lung Antibodies  >1 publications with HVCN1 and Lung
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000