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PLEKHM1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151010

PLEKHM1 Antibody: PLEKHM1 is a member of the M family of Pleckstrin homolog domain-containing proteins, a group of proteins containing a RUN domain, two pleckstrin homology domains, and a cysteine-rich domain. It was identified through segregation analysis as… More details

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Product Overview

Online Datasheet in PDF
Product Name
PLEKHM1, Polyclonal Antibody
Full Product Name
PLEKHM1 Antibody
Product Gene Name
anti-PLEKHM1 antibody
Product Synonym Names
PLEKHM1; B2; AP162; OPTB6; KIAA0356; Pleckstrin homology domain-containing family M member 1; 162 kDa adapter protein; PH domain-containing family M member 1; pleckstrin homology domain containing, family M (with RUN domain) member 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
PLEKHM1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
PLEKHM1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
PLEKHM1 peptide (MBS153062) is used for blocking the activity of PLEKHM1 antibody (MBS151010)
Molecular Weight
117,443 Da
OMIM
gene 611497
3D Structure
ModBase 3D Structure for Q9Y4G2
Conjugate
Unconjugated
Immunogen
PLEKHM1 antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human PLEKHM1.
Buffer
PLEKHM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-PLEKHM1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-PLEKHM1 antibody
PLEKHM1 antibody can be used for detection of PLEKHM1 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-PLEKHM1 antibody

Western blot analysis of PLEKHM1 in human lung tissue lysate with PLEKHM1 antibody at 1 μg/mL.
Rabbit Anti-PLEKHM1 Polyclonal Antibody – Cat# MBS151010

Immunohistochemistry (IHC) of anti-PLEKHM1 antibody

Immunohistochemistry of PLEKHM1 in human lung tissue with PLEKHM1 antibody at 5 μg/mL.
Rabbit Anti-PLEKHM1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151010

Immunofluorescence (IF) of anti-PLEKHM1 antibody

Immunofluorescence of PLKHM1 in human lung tissue with PLKHM1 antibody at 20 μg/mL.
Rabbit Anti-PLEKHM1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151010

Other Notes

Small volumes of anti-PLEKHM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLEKHM1 purchase

MBS151010 is an antibody targeting PLEKHM1. Also known as PLEKHM1 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PLEKHM1. It may not necessarily be applicable to this product.

NCBI GI #
160419247
NCBI GeneID
9842
NCBI Accession #
Q9Y4G2.3
UniProt Primary Accession #
Q9Y4G2
UniProt Secondary Accession #
Q6P2R5; Q8TEL9; Q9NPP5; Q9NYA0
UniProt Related Accession #
Q9Y4G2
NCBI Official Full Name
Pleckstrin homology domain-containing family M member 1
NCBI Official Synonym Full Names
pleckstrin homology domain containing, family M (with RUN domain) member 1
NCBI Official Symbol
PLEKHM1
NCBI Official Synonym Symbols
B2; AP162; OPTB6
UniProt Protein Name
Pleckstrin homology domain-containing family M member 1
UniProt Synonym Protein Names
162 kDa adapter protein; AP162
Protein Family
Pleckstrin homology domain-containing family
UniProt Gene Name
PLEKHM1
UniProt Synonym Gene Names
KIAA0356; PH domain-containing family M member 1; AP162
UniProt Entry Name
PKHM1_HUMAN
NCBI Protein Information
pleckstrin homology domain-containing family M member 1; 162 kDa adapter protein; PH domain-containing family M member 1

NCBI Summary for PLEKHM1

The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
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UniProt Comments for PLEKHM1

PLEKHM1: Involved in vesicular transport in the osteoclast. May have a role in sialyl-lex-mediated transduction of apoptotic signals. Defects in PLEKHM1 are the cause of osteopetrosis autosomal recessive type 6 (OPTB6); also known as autosomal recessive osteopetrosis intermediate form. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: cytoplasm

Molecular Function: metal ion binding

Disease: Osteopetrosis, Autosomal Recessive 6
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Research Articles on PLEKHM1

1. Rubicon and PLEKHM1 specifically and directly interact with Rab7 via their RH domain; this interaction is critical for their function; show Rubicon but not PLEKHM1 uniquely regulates membrane trafficking via simultaneously binding both Rab7 and PI3-kinase

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLEKHM1 antibody

 Reference Product  PubMed Publications
 CLCN7 antibody  >6 publications with PLEKHM1 and CLCN7

Diseases associated with anti-PLEKHM1 antibody

 Disease Name  Pubmed Publications
 Ovarian Neoplasms Antibodies  >1 publications with PLEKHM1 and Ovarian Neoplasms
 Lung Neoplasms Antibodies  >1 publications with PLEKHM1 and Lung Neoplasms
 Inflammation Antibodies  >1 publications with PLEKHM1 and Inflammation
 Osteopetrosis, Autosomal Recessive 6 Antibodies  >1 publications with PLEKHM1 and Osteopetrosis, Autosomal Recessive 6

Organs/Tissues associated with anti-PLEKHM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >11 publications with PLEKHM1 and Bone
 Blood Antibodies  >4 publications with PLEKHM1 and Blood
 Bone Marrow Antibodies  >3 publications with PLEKHM1 and Bone Marrow
 Kidney Antibodies  >1 publications with PLEKHM1 and Kidney
 Liver Antibodies  >1 publications with PLEKHM1 and Liver
 Intestine Antibodies  >1 publications with PLEKHM1 and Intestine
 Lung Antibodies  >1 publications with PLEKHM1 and Lung
 Spleen Antibodies  >1 publications with PLEKHM1 and Spleen
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