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STK17A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151045

DRAK1 Antibody: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DRAK1 (STK17A), Polyclonal Antibody
Full Product Name
DRAK1 Antibody
Product Gene Name
anti-STK17A antibody
Product Synonym Names
DRAK1; DRAK1; DRAK1; DAP kinase-related apoptosis-inducing protein kinase 1; serine/threonine kinase 17a
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid; DRAK1 Antibody is supplied in PBS containing 0.02%
Purity/Purification
DRAK1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/ml (lot specific)
Specificity
No cross responses to DRAK2, DAP or ZIP kinases.
Preparation and Storage
DRAK1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
DRAK1 peptide (MBS152587) is used for blocking the activity of DRAK1 antibody (MBS151045)
Molecular Weight
50 kDa
OMIM
604726
3D Structure
ModBase 3D Structure for Q9UEE5
Immunogen
DRAK1 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human DRAK1.
The immunogen is located within the first 50 amino acids of DRAK1.
Homology
Predicted species reactivity based on immunogen sequence: Rabbit: (73%)
Applications Tested/Suitable for anti-STK17A antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-STK17A antibody
DRAK1 antibody can be used for detection of DRAK1 by Western blot at 1 mug/mL. An approximately 50 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 2 mug/mL. For immunofluorescence start at 10 mug/mL.

Western Blot (WB) of anti-STK17A antibody

Western blot analysis of DRAK1 in (A) MOLT4 and (B) A431 whole cell lysates with DRAK1 antibody at 1 μg/mL.
Rabbit Anti-STK17A Polyclonal Antibody – Cat# MBS151045

Immunocytochemistry (IHC) of anti-STK17A antibody

Immunocytochemistry staining of MOLT4 cells using DRAK1 antibody at 2 μg/mL.
Rabbit Anti-STK17A Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS151045

Immunofluorescence (IF) of anti-STK17A antibody

Immunofluorescence of DRAK1 in Molt cells with DRAK1 antibody at 20 μg/mL.
Rabbit Anti-STK17A Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151045

Other Notes

Small volumes of anti-STK17A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STK17A purchase

MBS151045 is an antibody targeting STK17A. Also known as DRAK1 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STK17A. It may not necessarily be applicable to this product.

NCBI GI #
14423930
NCBI GeneID
9263
NCBI Accession #
Q9UEE5.1
UniProt Primary Accession #
Q9UEE5
UniProt Secondary Accession #
Q8IVC8; A4D1V6
UniProt Related Accession #
Q9UEE5
NCBI Official Full Name
Serine/threonine-protein kinase 17A
NCBI Official Synonym Full Names
serine/threonine kinase 17a
NCBI Official Symbol
STK17A
NCBI Official Synonym Symbols
DRAK1
UniProt Protein Name
Serine/threonine-protein kinase 17A
UniProt Synonym Protein Names
DAP kinase-related apoptosis-inducing protein kinase 1
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
STK17A
UniProt Synonym Gene Names
DRAK1
UniProt Entry Name
ST17A_HUMAN
NCBI Protein Information
serine/threonine-protein kinase 17A; death-associated protein kinase-related 1; serine/threonine kinase 17a (apoptosis-inducing); DAP kinase-related apoptosis-inducing protein kinase 1

NCBI Summary for STK17A

This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]

UniProt Comments for STK17A

DRAK1: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.

Protein type: Protein kinase, CAMK; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; DAPK family

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: nucleus

Molecular Function: protein serine/threonine kinase activity; ATP binding

Biological Process: apoptosis; positive regulation of apoptosis; protein amino acid phosphorylation
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Research Articles on STK17A

1. STK17A provides a proliferative and survival advantage to GBM cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-STK17A antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with STK17A and Nervous System Diseases
 Carcinoma, Squamous Cell Antibodies  >1 publications with STK17A and Carcinoma, Squamous Cell
 Pancreatic Neoplasms Antibodies  >1 publications with STK17A and Pancreatic Neoplasms
 Prostatic Neoplasms Antibodies  >1 publications with STK17A and Prostatic Neoplasms
 Uterine Cervical Neoplasms Antibodies  >1 publications with STK17A and Uterine Cervical Neoplasms
 Colonic Neoplasms Antibodies  >1 publications with STK17A and Colonic Neoplasms
 Kidney Diseases Antibodies  >1 publications with STK17A and Kidney Diseases
 Breast Neoplasms Antibodies  >1 publications with STK17A and Breast Neoplasms

Organs/Tissues associated with anti-STK17A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with STK17A and Blood
 Kidney Antibodies  >2 publications with STK17A and Kidney
 Bone Marrow Antibodies  >1 publications with STK17A and Bone Marrow
 Prostate Antibodies  >1 publications with STK17A and Prostate
 Bone Antibodies  >1 publications with STK17A and Bone
 Spleen Antibodies  >1 publications with STK17A and Spleen
 Brain Antibodies  >1 publications with STK17A and Brain
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