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FAM175A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151063

CCDC98 Antibody: CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the… More details

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Product Overview

Online Datasheet in PDF
Product Name
CCDC98 (FAM175A), Polyclonal Antibody
Full Product Name
CCDC98 Antibody
Product Gene Name
anti-FAM175A antibody
Product Synonym Names
CCDC98; ABRA1; CCDC98; ABRA1; UNQ496/PRO1013; BRCA1-A complex subunit Abraxas; Coiled-coil domain-containing protein 98; family with sequence similarity 175, member A
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
CCDC98 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
CCDC98 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
CCDC98 peptide (MBS152761) is used for blocking the activity of CCDC98 antibody (MBS151063)
Molecular Weight
46,663 Da
OMIM
phenotype 611143
3D Structure
ModBase 3D Structure for Q6UWZ7
Conjugate
Unconjugated
Immunogen
CCDC98 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human CCDC98.
Buffer
CCDC98 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-FAM175A antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FAM175A antibody
CCDC98 antibody can be used for detection of CCDC98 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.

Western Blot (WB) of anti-FAM175A antibody

Western blot analysis of CCDC98 in human breast tissue lysate in (A) the absence and (B) presence of blocking peptide with CCDC98 antibody at 1 μg/mL.
Rabbit Anti-FAM175A Polyclonal Antibody – Cat# MBS151063

Immunohistochemistry (IHC) of anti-FAM175A antibody

Immunohistochemistry of CCDC98 in human breast tissue with CCDC98 antibody at 5 μg/mL.
Rabbit Anti-FAM175A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151063

Other Notes

Small volumes of anti-FAM175A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FAM175A purchase

MBS151063 is an antibody targeting FAM175A. Also known as CCDC98 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FAM175A. It may not necessarily be applicable to this product.

NCBI GI #
109148531
NCBI GeneID
84142
NCBI Accession #
NP_620775
UniProt Primary Accession #
Q6UWZ7
UniProt Secondary Accession #
Q9H8I1; Q9H9N4; A5JJ07
UniProt Related Accession #
Q6UWZ7
GenBank Nucleotide #
NM_139076.2
NCBI Official Full Name
BRCA1-A complex subunit Abraxas
NCBI Official Synonym Full Names
family with sequence similarity 175, member A
NCBI Official Symbol
FAM175A
NCBI Official Synonym Symbols
ABRA1; CCDC98
UniProt Protein Name
BRCA1-A complex subunit Abraxas
UniProt Synonym Protein Names
Coiled-coil domain-containing protein 98; Protein FAM175A
Protein Family
BRCA1-A complex
UniProt Gene Name
FAM175A
UniProt Synonym Gene Names
ABRA1; CCDC98
UniProt Entry Name
F175A_HUMAN
NCBI Protein Information
BRCA1-A complex subunit Abraxas; abraxas protein; coiled-coil domain containing 98; coiled-coil domain-containing protein 98

UniProt Comments for FAM175A

Abraxas: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. Belongs to the FAM175 family. Abraxas subfamily.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 4q21.23

Cellular Component: nucleus

Molecular Function: protein binding; polyubiquitin binding

Biological Process: positive regulation of DNA repair; double-strand break repair; response to ionizing radiation; chromatin modification; G2/M transition DNA damage checkpoint
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Research Articles on FAM175A

1. The recurrent Abraxas c.1082G>A mutation connects to breast cancer predisposition.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FAM175A antibody

 Reference Product  PubMed Publications
 BRCA1 antibody  >23 publications with FAM175A and BRCA1
 BRCC3 antibody  >6 publications with FAM175A and BRCC3
 BRE antibody  >4 publications with FAM175A and BRE
 BARD1 antibody  >3 publications with FAM175A and BARD1
 ATM antibody  >2 publications with FAM175A and ATM
 MRE11A antibody  >2 publications with FAM175A and MRE11A
 RAD50 antibody  >1 publications with FAM175A and RAD50
 UIMC1 antibody  >1 publications with FAM175A and UIMC1

Diseases associated with anti-FAM175A antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >7 publications with FAM175A and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >5 publications with FAM175A and Ovarian Neoplasms

Organs/Tissues associated with anti-FAM175A antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with FAM175A and Lung
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