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ALKBH2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151067

ALKBH2 Antibody: The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA; ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ALKBH2, Polyclonal Antibody
Full Product Name
ALKBH2 Antibody
Product Gene Name
anti-ALKBH2 antibody
Product Synonym Names
ALKBH2; ABH2; ABH2; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; Alkylated DNA repair protein alkB homolog 2; alkB, alkylation repair homolog 2 (E. coli)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
ALKBH2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
ALKBH2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
ALKBH2 peptide (MBS152620) is used for blocking the activity of ALKBH2 antibody (MBS151067)
Molecular Weight
17,083 Da
OMIM
610602
3D Structure
ModBase 3D Structure for Q6NS38
Conjugate
Unconjugated
Immunogen
ALKBH2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ALKBH2.
Buffer
ALKBH2 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-ALKBH2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ALKBH2 antibody
ALKBH2 antibody can be used for detection of ALKBH2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL.

Western Blot (WB) of anti-ALKBH2 antibody

Western blot analysis of ALKBH2 in human kidney tissue lysate with ALKBH2 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-ALKBH2 Polyclonal Antibody – Cat# MBS151067

Immunohistochemistry (IHC) of anti-ALKBH2 antibody

Immunohistochemistry of ALKBH2 in human kidney tissue with ALKBH2 antibody at 10 μg/mL.
Rabbit Anti-ALKBH2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151067

Other Notes

Small volumes of anti-ALKBH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALKBH2 purchase

MBS151067 is an antibody targeting ALKBH2. Also known as ALKBH2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALKBH2. It may not necessarily be applicable to this product.

NCBI GI #
224451107
NCBI GeneID
121642
NCBI Accession #
NP_001138847
UniProt Primary Accession #
Q6NS38
UniProt Secondary Accession #
Q5XLE3; A4PET2
UniProt Related Accession #
Q6NS38
GenBank Nucleotide #
NM_001145375.1
NCBI Official Full Name
alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 isoform 1
NCBI Official Synonym Full Names
alkB, alkylation repair homolog 2 (E. coli)
NCBI Official Symbol
ALKBH2
NCBI Official Synonym Symbols
ABH2
UniProt Protein Name
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
UniProt Synonym Protein Names
Alkylated DNA repair protein alkB homolog 2; DNA oxidative demethylase ALKBH2; Oxy DC1
Protein Family
DNA oxidative demethylase
UniProt Gene Name
ALKBH2
UniProt Synonym Gene Names
ABH2
UniProt Entry Name
ALKB2_HUMAN
NCBI Protein Information
alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; oxy DC1; 2OG-Fe(II) oxy DC1; DNA oxidative demethylase ALKBH2; alkylated DNA repair protein alkB homolog 2

NCBI Summary for ALKBH2

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
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UniProt Comments for ALKBH2

ALKBH2: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; DNA repair, damage; Oxidoreductase; EC 1.14.11.33; Demethylase

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus

Molecular Function: ferrous iron binding; DNA-N1-methyladenine dioxygenase activity; DNA demethylase activity

Biological Process: DNA dealkylation; DNA repair
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Research Articles on ALKBH2

1. ABH2 knockdown impairs rDNA transcription and leads to increased single-stranded and double-stranded DNA breaks in the rDNA genes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALKBH2 antibody

 Reference Product  PubMed Publications
 ALKBH1 antibody  >4 publications with ALKBH2 and ALKBH1
 ALKBH8 antibody  >2 publications with ALKBH2 and ALKBH8
 ALKBH7 antibody  >1 publications with ALKBH2 and ALKBH7
 ALKBH4 antibody  >1 publications with ALKBH2 and ALKBH4
 ALKBH5 antibody  >1 publications with ALKBH2 and ALKBH5
 PCNA antibody  >1 publications with ALKBH2 and PCNA

Pathways associated with anti-ALKBH2 antibody

 Products by Pathway  Pathway Diagram
 ABH2 Mediated Reversal Of Alkylation Damage Pathway antibodies  ABH2 Mediated Reversal Of Alkylation Damage Pathway Diagram
 DNA Damage Reversal Pathway antibodies  DNA Damage Reversal Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Reversal Of Alkylation Damage By DNA Dioxygenases Pathway antibodies  Reversal Of Alkylation Damage By DNA Dioxygenases Pathway Diagram

Diseases associated with anti-ALKBH2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with ALKBH2 and Nervous System Diseases
 Inflammation Antibodies  >2 publications with ALKBH2 and Inflammation

Organs/Tissues associated with anti-ALKBH2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with ALKBH2 and Brain
 Pancreas Antibodies  >1 publications with ALKBH2 and Pancreas
 Intestine Antibodies  >1 publications with ALKBH2 and Intestine
 Stomach Antibodies  >1 publications with ALKBH2 and Stomach
 Lung Antibodies  >1 publications with ALKBH2 and Lung
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