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LASS5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151087

LASS5 Antibody: The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are… More details

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Product Overview

Online Datasheet in PDF
Product Name
LASS5, Polyclonal Antibody
Full Product Name
LASS5 Antibody
Product Gene Name
anti-LASS5 antibody
Product Synonym Names
LASS5; Trh4; LASS5; Ceramide synthase 5; LAG1 longevity assurance homolog 5; CerS5; LAG1 homolog, ceramide synthase 5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
LASS5 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
Multiple isoforms of LASS5 are known to exist. This antibody may cross-react with the highly homologous LASS6.
Preparation and Storage
LASS5 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
LASS5 peptide (MBS152522) is used for blocking the activity of LASS5 antibody (MBS151087)
Molecular Weight
39,259 Da
OMIM
615335
3D Structure
ModBase 3D Structure for Q8N5B7
Conjugate
Unconjugated
Immunogen
LASS5 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human LASS5.
Buffer
LASS5 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-LASS5 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-LASS5 antibody
LASS5 antibody can be used for detection of LASS5 by Western blot at 1 mug/mL. Antibody can also be used for immunoflourescence starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-LASS5 antibody

Western blot analysis of LASS5 in SK-N-SH lysate with LASS5 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.
Rabbit Anti-LASS5 Polyclonal Antibody – Cat# MBS151087

Immunofluorescence (IF) of anti-LASS5 antibody

Immunofluorescence of LASS5 in human brain tissue with LASS5 antibody at 20 μg/mL.
Rabbit Anti-LASS5 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151087

Immunofluorescence (IF) of anti-LASS5 antibody

Immunofluorescence of LASS5 in Human Brain cells with LASS5 antibody at 20 μg/mL.
Rabbit Anti-LASS5 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151087

Other Notes

Small volumes of anti-LASS5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LASS5 purchase

MBS151087 is an antibody targeting LASS5. Also known as LASS5 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LASS5. It may not necessarily be applicable to this product.

NCBI GI #
22218345
NCBI GeneID
91012
NCBI Accession #
NP_671723
UniProt Primary Accession #
Q8N5B7
UniProt Secondary Accession #
B4DV54
UniProt Related Accession #
Q8N5B7
GenBank Nucleotide #
NM_147190.3
NCBI Official Full Name
ceramide synthase 5 isoform 1
NCBI Official Synonym Full Names
ceramide synthase 5
NCBI Official Symbol
CERS5
NCBI Official Synonym Symbols
Trh4; LASS5
UniProt Protein Name
Ceramide synthase 5
UniProt Synonym Protein Names
LAG1 longevity assurance homolog 5
UniProt Gene Name
CERS5
UniProt Synonym Gene Names
LASS5; CerS5
UniProt Entry Name
CERS5_HUMAN
NCBI Protein Information
ceramide synthase 5; LAG1 homolog, ceramide synthase 5; LAG1 longevity assurance homolog 5

NCBI Summary for LASS5

This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for LASS5

LASS5: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl- (C16) ceramide) in a fumonisin B1-independent manner.

Protein type: DNA-binding; EC 2.3.1.24; Membrane protein, multi-pass; Transferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q13.12

Cellular Component: endoplasmic reticulum membrane; nuclear membrane; endoplasmic reticulum; integral to membrane

Molecular Function: DNA binding; sphingosine N-acyltransferase activity

Biological Process: sphingolipid metabolic process; sphingolipid biosynthetic process; ceramide biosynthetic process
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Research Articles on LASS5

1. Overexpression of CerS5 increased apoptosis in HeLa cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LASS5 antibody

 Reference Product  PubMed Publications
 CLN8 antibody  >2 publications with LASS5 and CLN8
 SPHK2 antibody  >1 publications with LASS5 and SPHK2

Pathways associated with anti-LASS5 antibody

 Products by Pathway  Pathway Diagram
 Ceramide Biosynthesis Pathway antibodies  Ceramide Biosynthesis Pathway Diagram
 Ceramide Biosynthesis Pathway antibodies  Ceramide Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid De Novo Biosynthesis Pathway antibodies  Sphingolipid De Novo Biosynthesis Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram

Diseases associated with anti-LASS5 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with LASS5 and Inflammation
 Breast Neoplasms Antibodies  >1 publications with LASS5 and Breast Neoplasms
 Liver Diseases Antibodies  >1 publications with LASS5 and Liver Diseases
 Necrosis Antibodies  >1 publications with LASS5 and Necrosis

Organs/Tissues associated with anti-LASS5 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >2 publications with LASS5 and Nerve
 Muscle Antibodies  >2 publications with LASS5 and Muscle
 Lung Antibodies  >2 publications with LASS5 and Lung
 Brain Antibodies  >2 publications with LASS5 and Brain
 Adipose Tissue Antibodies  >1 publications with LASS5 and Adipose Tissue
 Liver Antibodies  >1 publications with LASS5 and Liver
 Kidney Antibodies  >1 publications with LASS5 and Kidney
 Blood Antibodies  >1 publications with LASS5 and Blood
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