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TNFRSF17 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151091

BCMA Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
BCMA (TNFRSF17), Polyclonal Antibody
Full Product Name
BCMA Antibody
Product Gene Name
Product Synonym Names
BCMA; BCM; BCMA; CD269; TNFRSF13A; BCM; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; tumor necrosis factor receptor superfamily, member 17
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid; Supplied in PBS containing 0.02% sodium azide.
Purity/Purification
BCMA Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
Antibody can be stored at 4 degree C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
BCMA peptide (MBS152462) is used for blocking the activity of BCMA antibody (MBS151091)
Molecular Weight
Predicted: 20 kDa
Observed: 27 kDa
OMIM
109545
3D Structure
ModBase 3D Structure for Q02223
Conjugate
Unconjugated
Immunogen
BCMA antibody was raised against a synthetic peptide mapping at the carboxy terminus of human BCMA.
The immunogen is located within the last 50 amino acids of BCMA.
Positive Control
1) Cat. No. MBS151739 - K562 Cell Lysate
2) Cat. No. MBS151695 - U937 Cell Lysate
3) Cat. No. MBS151674 - Human Spleen Tissue Lysate
4) Cat. No. MBS154333 - Human Spleen Tissue Slide
Applications Tested/Suitable for anti-TNFRSF17 antibody
ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB)
Application Notes for anti-TNFRSF17 antibody
BCMA antibody can be used for detection of BCMA by Western blot at 5 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Optimal dilutions for each application to be determined by the researcher.

Western Blot (WB) of anti-TNFRSF17 antibody

Western blot analysis of BCMA in (A) human spleen tissue lysate, (B) K562, and (C) U937 cell lysates with BCMA antibody at 5 μg/mL.
Rabbit Anti-TNFRSF17 Polyclonal Antibody – Cat# MBS151091

Immunohistochemistry (IHC) of anti-TNFRSF17 antibody

Immunohistochemistry of BCMA in human spleen tissue with BCMA antibody at 5 μg/mL.
Rabbit Anti-TNFRSF17 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151091

Immunohistochemistry (IHC) of anti-TNFRSF17 antibody

Immunohistochemistry of BCMA in human spleen tissue with BCMA antibody at 10 μg/mL.
Rabbit Anti-TNFRSF17 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151091

Immunofluorescence (IF) of anti-TNFRSF17 antibody

Immunofluorescence of BCMA in Human Spleen tissue with BCMA antibody at 10 μg/mL.
Rabbit Anti-TNFRSF17 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151091

Other Notes

Small volumes of anti-TNFRSF17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF17 purchase

MBS151091 is an antibody targeting TNFRSF17. Also known as BCMA Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF17. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 17
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 17
NCBI Official Symbol
TNFRSF17
NCBI Official Synonym Symbols
BCM; BCMA; CD269; TNFRSF13A
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 17
UniProt Synonym Protein Names
B-cell maturation protein; CD_antigen: CD269
UniProt Gene Name
TNFRSF17
UniProt Synonym Gene Names
BCM; BCMA
UniProt Entry Name
TNR17_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein

NCBI Summary for TNFRSF17

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
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UniProt Comments for TNFRSF17

TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Protein type: Oncoprotein; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: integral to membrane; plasma membrane; endomembrane system

Molecular Function: receptor activity

Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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