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STK39 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151101

Stk39 Antibody: The serine/threonine kinase Stk39 belongs to the STE20 family, a group of kinases that are known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKC-theta, WNK and MLCK), and with transcription factor AP-1. The STE 20… More details

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Product Overview

Online Datasheet in PDF
Product Name
Stk39, Polyclonal Antibody
Full Product Name
Stk39 Antibody
Product Gene Name
anti-STK39 antibody
Product Synonym Names
Stk39; DCHT; PASK; SPAK; DCHT; Ste-20-related kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
Stk39 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
Stk39 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
Stk39 peptide (MBS152987) is used for blocking the activity of Stk39 antibody (MBS151101)
Molecular Weight
57,937 Da
OMIM
607648
3D Structure
ModBase 3D Structure for Q9UEW8
Conjugate
Unconjugated
Immunogen
Stk39 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human Stk39.
Buffer
Stk39 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-STK39 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-STK39 antibody
Stk39 antibody can be used for detection of stk39 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-STK39 antibody

Western blot analysis of Stk39 in SK-N-SH cell lysate with Stk39 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-STK39 Polyclonal Antibody – Cat# MBS151101

Immunohistochemistry (IHC) of anti-STK39 antibody

Immunohistochemistry of Stk39 in human brain tissue with Stk39 antibody at 2.5 μg/mL.
Rabbit Anti-STK39 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151101

Immunofluorescence (IF) of anti-STK39 antibody

Immunofluorescence of stk39 in human brain tissue with stk39 antibody at 20 μg/mL.
Rabbit Anti-STK39 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151101

Other Notes

Small volumes of anti-STK39 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STK39 purchase

MBS151101 is an antibody targeting STK39. Also known as Stk39 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STK39. It may not necessarily be applicable to this product.

NCBI GI #
115430252
NCBI GeneID
27347
NCBI Accession #
NP_037365
UniProt Primary Accession #
Q9UEW8
UniProt Secondary Accession #
O14774; Q53S90; Q53SL7; Q53SS1; Q9UER4; X5D9C8
UniProt Related Accession #
Q9UEW8
GenBank Nucleotide #
NM_013233.2
NCBI Official Full Name
STE20/SPS1-related proline-alanine-rich protein kinase
NCBI Official Synonym Full Names
serine threonine kinase 39
NCBI Official Symbol
STK39
NCBI Official Synonym Symbols
DCHT; PASK; SPAK
UniProt Protein Name
STE20/SPS1-related proline-alanine-rich protein kinase
UniProt Synonym Protein Names
DCHT; Serine/threonine-protein kinase 39
Protein Family
STE20/SPS1-related proline-alanine-rich protein kinase
UniProt Gene Name
STK39
UniProt Synonym Gene Names
SPAK; Ste-20-related kinase
UniProt Entry Name
STK39_HUMAN
NCBI Protein Information
STE20/SPS1-related proline-alanine-rich protein kinase; STE20/SPS1 homolog; ste-20-related kinase; Ste20-like protein kinase; small intestine SPAK-like kinase; serine/threonine-protein kinase 39; proline-alanine-rich STE20-related kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast)

NCBI Summary for STK39

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
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UniProt Comments for STK39

STLK3: May act as a mediator of stress-activated signals. The phosphorylated form forms a complex with WNK2. Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Protein type: Kinase, protein; Protein kinase, STE; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; FRAY subfamily

Chromosomal Location of Human Ortholog: 2q24.3

Cellular Component: cytoskeleton; basolateral plasma membrane; cytoplasm; apical plasma membrane; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: peptidyl-serine phosphorylation; positive regulation of potassium ion transport; regulation of inflammatory response; peptidyl-threonine phosphorylation; response to stress; protein amino acid phosphorylation
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Research Articles on STK39

1. SPAK short forms in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STK39 antibody

 Reference Product  PubMed Publications
 WNK4 antibody  >37 publications with STK39 and WNK4
 SLC12A2 antibody  >24 publications with STK39 and SLC12A2
 SLC12A1 antibody  >15 publications with STK39 and SLC12A1
 SLC12A6 antibody  >2 publications with STK39 and SLC12A6
 PRKCQ antibody  >2 publications with STK39 and PRKCQ
 SP1 antibody  >1 publications with STK39 and SP1
 MAPK14 antibody  >1 publications with STK39 and MAPK14

Pathways associated with anti-STK39 antibody

 Products by Pathway  Pathway Diagram
 TCR Signaling In Naive CD4+ T Cells Pathway antibodies  TCR Signaling In Naive CD4+ T Cells Pathway Diagram

Diseases associated with anti-STK39 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >61 publications with STK39 and Hypertension
 Cardiovascular Diseases Antibodies  >35 publications with STK39 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >21 publications with STK39 and Kidney Diseases
 Disease Models, Animal Antibodies  >11 publications with STK39 and Disease Models, Animal
 Inflammation Antibodies  >5 publications with STK39 and Inflammation
 Fibrosis Antibodies  >4 publications with STK39 and Fibrosis
 Breast Neoplasms Antibodies  >3 publications with STK39 and Breast Neoplasms
 Necrosis Antibodies  >2 publications with STK39 and Necrosis
 Prostatic Neoplasms Antibodies  >2 publications with STK39 and Prostatic Neoplasms
 Autistic Disorder Antibodies  >2 publications with STK39 and Autistic Disorder

Organs/Tissues associated with anti-STK39 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >63 publications with STK39 and Blood
 Kidney Antibodies  >53 publications with STK39 and Kidney
 Brain Antibodies  >14 publications with STK39 and Brain
 Heart Antibodies  >8 publications with STK39 and Heart
 Muscle Antibodies  >5 publications with STK39 and Muscle
 Intestine Antibodies  >5 publications with STK39 and Intestine
 Prostate Antibodies  >4 publications with STK39 and Prostate
 Lung Antibodies  >3 publications with STK39 and Lung
 Pancreas Antibodies  >2 publications with STK39 and Pancreas
 Bone Antibodies  >2 publications with STK39 and Bone
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